CAJ | 학술논문

目的：初步考察咖啡渣提取物的急性毒性与抗炎作用。方法：采用小鼠最大耐受剂量法观察咖啡渣提取物的急性毒性作用，分别用二甲苯与醋酸诱导小鼠急性炎症模型，连续7天分别灌胃给予咖啡渣提取物1.00，2.00，3.00 g·kg-1（按生药量计）。重量法检测小鼠耳肿胀率，伊文思蓝法检测小鼠腹腔毛细血管通透性，观察咖啡渣对炎症小鼠的抗炎作用。结果：咖啡渣提取物的小鼠最大耐受量为8.60 g·kg-1（按生药量计），咖啡渣提取物3.00 g·kg-1能降低二甲苯导致的小鼠耳肿胀率（P<0.05），抑制醋酸导致的小鼠毛细血管通透性增加（P<0.05）。结论：咖啡渣提取物对小鼠具有一定的抗炎作用。
목적：초보고찰가배사제취물적급성독성여항염작용。방법：채용소서최대내수제량법관찰가배사제취물적급성독성작용，분별용이갑분여작산유도소서급성염증모형，련속7천분별관위급여가배사제취물1.00，2.00，3.00 g·kg-1（안생약량계）。중량법검측소서이종창솔，이문사람법검측소서복강모세혈관통투성，관찰가배사대염증소서적항염작용。결과：가배사제취물적소서최대내수량위8.60 g·kg-1（안생약량계），가배사제취물3.00 g·kg-1능강저이갑분도치적소서이종창솔（P<0.05），억제작산도치적소서모세혈관통투성증가（P<0.05）。결론：가배사제취물대소서구유일정적항염작용。
This study was aimed to preliminarily evaluate the acute toxicity and anti-inflammatory effects of coffee residue extract. The test maximum tolerated dose was applied in mice by gavage to observe the acute toxicity of coffee residue extract. Mice acute inflammation model was induced by xylene and glacial acetic acid. The gavage administration of coffee residue extract (1.00, 2.00, 3.00 g?kg-1, in terms of crude drug) was given 7 days con-tinuously. The ear swelling rate and celiac capillary permeability were measured. The results showed that the ex-tract of coffee residue maximum tolerated dose in mice is 8 . 60 g?kg -1 ( in terms of crude drug ) . The coffee residue extract of 3 . 00 g?kg-1 is able to inhibit ear swelling induced by xylene in mice ( P < 0 . 05 ) and the ex-cessive celiac capillary permeability ( P < 0 . 05 ) . It was concluded that the coffee residue extract have certain an-ti-inflammation activities.