世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2013年
4期
659-663
,共5页
陈有军%向飞军%金嘉文%侯少贞%许冬瑾%马兴田
陳有軍%嚮飛軍%金嘉文%侯少貞%許鼕瑾%馬興田
진유군%향비군%금가문%후소정%허동근%마흥전
何首乌%炮制%血虚%补血
何首烏%砲製%血虛%補血
하수오%포제%혈허%보혈
R adix Polygoni Multiflori%processing%blood deficiency%blood-enriching effect
目的：考察何首乌不同炮制品对大鼠血虚模型的补血作用并探讨其最佳炮制方法。方法：140只SD大鼠，随机分为空白组、模型组、阳性药物组和11个不同何首乌炮制品组，每组10只，分别灌胃给予蒸馏水、血宝补血冲剂（阳性对照药）和不同何首乌炮制品（剂量均为生药含量2 g·kg-1），每天1次，连续10天，于第10天时取血检查各组动物红细胞、红血球蛋白、红细胞压积、全血和血浆黏度和凝血酶原时间等指标。结果：何首乌常压豆制24h、常压酒豆制24h、高压清蒸4h和8h、高压豆制6h和8h组、高压酒制6h以及高压酒豆制8h组能显著增加血虚大鼠模型的红细胞数量和血红蛋白数量，其中高压豆制何首乌8 h组红细胞和血红蛋白数增加效果最佳（P<0.01）。生何首乌、常压豆制24 h、酒制24 h、酒豆制24 h，高压清蒸4h和8h、高压豆制6h和8h以及高压酒制6h能够改善血虚大鼠模型的血流变功能紊乱（P<0.05或P<0.01）。结论：何首乌以黑豆汁或酒为辅料，高压蒸制6～8 h，补血效果更好。
目的：攷察何首烏不同砲製品對大鼠血虛模型的補血作用併探討其最佳砲製方法。方法：140隻SD大鼠，隨機分為空白組、模型組、暘性藥物組和11箇不同何首烏砲製品組，每組10隻，分彆灌胃給予蒸餾水、血寶補血遲劑（暘性對照藥）和不同何首烏砲製品（劑量均為生藥含量2 g·kg-1），每天1次，連續10天，于第10天時取血檢查各組動物紅細胞、紅血毬蛋白、紅細胞壓積、全血和血漿黏度和凝血酶原時間等指標。結果：何首烏常壓豆製24h、常壓酒豆製24h、高壓清蒸4h和8h、高壓豆製6h和8h組、高壓酒製6h以及高壓酒豆製8h組能顯著增加血虛大鼠模型的紅細胞數量和血紅蛋白數量，其中高壓豆製何首烏8 h組紅細胞和血紅蛋白數增加效果最佳（P<0.01）。生何首烏、常壓豆製24 h、酒製24 h、酒豆製24 h，高壓清蒸4h和8h、高壓豆製6h和8h以及高壓酒製6h能夠改善血虛大鼠模型的血流變功能紊亂（P<0.05或P<0.01）。結論：何首烏以黑豆汁或酒為輔料，高壓蒸製6～8 h，補血效果更好。
목적：고찰하수오불동포제품대대서혈허모형적보혈작용병탐토기최가포제방법。방법：140지SD대서，수궤분위공백조、모형조、양성약물조화11개불동하수오포제품조，매조10지，분별관위급여증류수、혈보보혈충제（양성대조약）화불동하수오포제품（제량균위생약함량2 g·kg-1），매천1차，련속10천，우제10천시취혈검사각조동물홍세포、홍혈구단백、홍세포압적、전혈화혈장점도화응혈매원시간등지표。결과：하수오상압두제24h、상압주두제24h、고압청증4h화8h、고압두제6h화8h조、고압주제6h이급고압주두제8h조능현저증가혈허대서모형적홍세포수량화혈홍단백수량，기중고압두제하수오8 h조홍세포화혈홍단백수증가효과최가（P<0.01）。생하수오、상압두제24 h、주제24 h、주두제24 h，고압청증4h화8h、고압두제6h화8h이급고압주제6h능구개선혈허대서모형적혈류변공능문란（P<0.05혹P<0.01）。결론：하수오이흑두즙혹주위보료，고압증제6～8 h，보혈효과경호。
This study was aimed to investigate the blood-enriching effect of processed Radix Polygoni Multiflori on blood deficiency rats. A total of 140 SD rats were randomly divided into 14 groups, which were the blank control group, blood deficiency model group, positive control group and 11 test groups. The blank control group and model control group were treated with distilled water and the positive control group was given X ue b ao Buxue soluble granules. The test groups were treated with 11 different kinds of processed Radix Polygoni Multiflori sam-ples at a dosage of 2 g?kg-1 respectively. All rats were given drugs once a day. After 10 days, blood samples were collected and the amount of red blood cell (RBC), hemoglobin (Hb), haematocrit (HCT), whole blood viscos-ity and plasma viscosity, prothrombin time were estimated. The results showed that 9 processed Radix Polygoni Multiflori groups can increase the number of RBC and Hb significantly ( P < 0 . 05 or P < 0 . 01 ) in blood deficien-cy rat models. They were the sample processed with decoction of black soybean (DBS) for 24 h, with wine and DBS combination for 24 h , steamed for 4 h and 8 h under high pressure , with DBS for 6 h and 8 h , with wine for 6 h, with wine and DBS combination under high pressure, respectively. The samples processed with DBS un-der high pressure for 8 h increased RBC and Hb were more obviously ( P < 0 . 01 ) . The 8 groups can improve the situation of functional disorder of blood rheology significantly ( P < 0 . 05 or P < 0 . 01 ) . They were the unprocessed samples, processed with DBS and wine for 24 h respectively, with DBS and wine combination for 24 h, steamed for 4 h and 8 h or steamed with DBS for 6 h and 8 h or with wine for 6 h under high pressure respectively. It was concluded that the blood-enriching effect was improved while the R adix Polygoni Multiflori was processed with DBS or wine and under high pressure for 6-8 h .
