CAJ | 학술논문

“病证效”结合的临床模式是中西医结合医学发展的趋势，该模式在病证结合的基础上进行综合的疗效评价，能够凸显中医临床诊疗的优势。机体在病证状态和药物作用下，引起全身水平的内源性代谢物及代谢网络变化。运用代谢组学技术考察和分析这些代谢的变化，可以探究病证本质，阐明药物作用机理。本文对近年来代谢组学在“病证效”结合研究中的应用进行综述，将代谢组学运用到“病证效”结合研究中，有助于促进中西医结合的发展。
“병증효”결합적림상모식시중서의결합의학발전적추세，해모식재병증결합적기출상진행종합적료효평개，능구철현중의림상진료적우세。궤체재병증상태화약물작용하，인기전신수평적내원성대사물급대사망락변화。운용대사조학기술고찰화분석저사대사적변화，가이탐구병증본질，천명약물작용궤리。본문대근년래대사조학재“병증효”결합연구중적응용진행종술，장대사조학운용도“병증효”결합연구중，유조우촉진중서의결합적발전。
As an important clinical mode, the "disease-syndrome-efficacy" integration is a development trend of traditional Chinese medicine (TCM) and western medicine combination. The mode combined comprehensive effica-cy evaluation based on "disease-syndrome" integration is able to highlight advantages of TCM clinical diagnosis and treatment. With the status of disease-syndrome and effects of Chinese herbal medicine treatments, the en-dogenous metabolites and metabolic network of body changed in the systemic level. According to the analysis of these metabolic changes by metabolomic technologies, it is helpful to investigate the essence of disease-syndrome and explain the mechanism of Chinese herbal medicine actions. This review summarized the current applications of metabolomics in the area of "disease-syndrome-efficacy" integration research . Metabolomics applied in the "disease-syndrome-efficacy" integration research is helpful to facilitate the development of TCM and western medicine combination .