CAJ | 학술논문

目的：研究注射用血塞通在不同溶剂中的溶出情况。方法：分别采用专用溶剂（注：原标准中规定）、注射用水、氯化钠注射液和5％葡萄糖注射液对注射用血塞通进行溶解，在不同振摇时间点取样测定有效成分三七皂苷R1，人参皂苷Rg1，人参皂苷Re，人参皂苷Rb1和人参皂苷Rd的含量，比较不同溶剂的溶出率曲线。结果：专用溶剂的溶出速率最快，但注射用水、氯化钠注射液和5％葡萄糖注射液也能在1 min内达到有效成分的完全溶解。结论：注射用水、氯化钠注射液和5％葡萄糖注射液可替代专用溶剂作为注射用血塞通的溶剂。
목적：연구주사용혈새통재불동용제중적용출정황。방법：분별채용전용용제（주：원표준중규정）、주사용수、록화납주사액화5％포도당주사액대주사용혈새통진행용해，재불동진요시간점취양측정유효성분삼칠조감R1，인삼조감Rg1，인삼조감Re，인삼조감Rb1화인삼조감Rd적함량，비교불동용제적용출솔곡선。결과：전용용제적용출속솔최쾌，단주사용수、록화납주사액화5％포도당주사액야능재1 min내체도유효성분적완전용해。결론：주사용수、록화납주사액화5％포도당주사액가체대전용용제작위주사용혈새통적용제。
Objective:To study the digestion rate of Xuesaitong injection in different dissolving solutions.Methods:Xuesaitong injec-tion was dissolved in special solvents , water for injection , sodium chloride injection and 5% glucose injection respectively , and the contents of the effective components including notoginsenoside R 1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd were tested in different shaking time , then the curves of digestion rate of diffferent dissolving solutions were compared.Results:The digestion rate of the special solvent was the fastest , but the effective components could also be dissolved completely in water for in-jection, sodium chloride injection and 5%glucose injection within 1 minute.Conclusion:Water for injection, sodium chloride injec-tion and 5%glucose injection can replace the special solvent and to be used as the dissolving solution of Xuesaitong injection .