中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
5期
2060-2063
,共4页
马静%张瑞%刘近春
馬靜%張瑞%劉近春
마정%장서%류근춘
髓系衍生抑制性细胞%结肠炎,溃疡性%结肠肿瘤%氧化偶氮甲烷%葡聚糖硫酸钠
髓繫衍生抑製性細胞%結腸炎,潰瘍性%結腸腫瘤%氧化偶氮甲烷%葡聚糖硫痠鈉
수계연생억제성세포%결장염,궤양성%결장종류%양화우담갑완%포취당류산납
Myeloid-derived suppressor cells%Colitis,ulcerative%Colonic neoplasms%Azoxymethane%Dextran sodium sulfate
目的研究溃疡性结肠炎相关性结肠癌小鼠骨髓及脾脏中髓系衍生抑制性细胞( MDSCs)比例的变化,探讨其在结肠癌发生发展中的作用。方法采用氧化偶氮甲烷( AOM)联合葡聚糖硫酸钠( DSS)建立溃疡性结肠炎癌变的动物模型,同时流式细胞仪检测正常小鼠、溃疡性结肠炎小鼠、癌变小鼠骨髓和脾脏中MDSCs的比例。结果溃疡性结肠炎及溃疡性结肠炎相关性结肠癌小鼠骨髓和脾脏中MDSCs的比例较正常小鼠显著增高( P<0.05)。结论 AOM联合DSS所诱导的溃疡性结肠炎相关性结肠癌小鼠骨髓和脾脏中MDSCs比例的增加与结肠癌发生发展密切相关。
目的研究潰瘍性結腸炎相關性結腸癌小鼠骨髓及脾髒中髓繫衍生抑製性細胞( MDSCs)比例的變化,探討其在結腸癌髮生髮展中的作用。方法採用氧化偶氮甲烷( AOM)聯閤葡聚糖硫痠鈉( DSS)建立潰瘍性結腸炎癌變的動物模型,同時流式細胞儀檢測正常小鼠、潰瘍性結腸炎小鼠、癌變小鼠骨髓和脾髒中MDSCs的比例。結果潰瘍性結腸炎及潰瘍性結腸炎相關性結腸癌小鼠骨髓和脾髒中MDSCs的比例較正常小鼠顯著增高( P<0.05)。結論 AOM聯閤DSS所誘導的潰瘍性結腸炎相關性結腸癌小鼠骨髓和脾髒中MDSCs比例的增加與結腸癌髮生髮展密切相關。
목적연구궤양성결장염상관성결장암소서골수급비장중수계연생억제성세포( MDSCs)비례적변화,탐토기재결장암발생발전중적작용。방법채용양화우담갑완( AOM)연합포취당류산납( DSS)건립궤양성결장염암변적동물모형,동시류식세포의검측정상소서、궤양성결장염소서、암변소서골수화비장중MDSCs적비례。결과궤양성결장염급궤양성결장염상관성결장암소서골수화비장중MDSCs적비례교정상소서현저증고( P<0.05)。결론 AOM연합DSS소유도적궤양성결장염상관성결장암소서골수화비장중MDSCs비례적증가여결장암발생발전밀절상관。
Objective The role of myeloid derived suppressed cells in the development of ulcerative colitis -associated colorectal cancer was studied .Methods Ulcerative colitis-associated colorectal cancer in mice was established by a single intraperitoneal administration (10 mg/kg body weight)of AOM and 3 cycles oral exposure(in drinking water ) to DSS( molecular weight 36 000-50 000 ,2%) .The proportion of MDSCs in marrow and spleen was measured by flow cytometry .Results The proportion of marrow and spleen MDSCs in tumor bearing mice was significantly higher than in normal mice ( P<0.05 ) .Accompanying with tumor progression ,the proportion of marrow and spleen MDSCs increased gradually .Conclusions The proportion of marrow and spleen MDSCs in mice is associated with tumor progression .