中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
5期
1995-1998
,共4页
张枫林%赵庆娜%胡有东%李侠
張楓林%趙慶娜%鬍有東%李俠
장풍림%조경나%호유동%리협
心肌梗死%心肌成形术%老年人%抗原, CD34%抗原, CD31%抗原, CD14%受体,IgG
心肌梗死%心肌成形術%老年人%抗原, CD34%抗原, CD31%抗原, CD14%受體,IgG
심기경사%심기성형술%노년인%항원, CD34%항원, CD31%항원, CD14%수체,IgG
Myocardial infarction%Cardiomyoplasty%Aged%Antigens,CD34%Antigens,CD31%Antigens,CD14%Receptors,IgG
目的探讨人脐带间充质干细胞治疗老年人陈旧性心肌梗死的外周血CD34+、CD31+和CD14+CD16+表达水平。方法采用流式细胞仪检测经皮冠状动脉介入治疗( PCI )+支架植入术患者和PCI+支架植入术+人脐带造血干细胞( hUCM-SCs )移植术患者循环CD34+、CD31+和CD14+CD16+的表达水平、心肌梗死面积和左心室射血分数( LVEF)。评估CD34+、CD31+和CD14+CD16+对细胞心肌成形术早期预后的影响。结果两组治疗前各指标无统计学差异。 PCI +支架植入术后8周梗死面积(26.6±3.4)%、LVEF(38.4±2.8)%;PCI+支架植入术+hUCM-SCs 移植后8周梗死面积(24.2±3.9)%、LVEF (46.1±1.9)%,两者比较均P<0.01。 PCI+支架植入术后8周CD34+(0.9±0.2)×109/L、CD31+(437±40)个/μl和CD14+CD16+(0.9±0.2)%,PCI+支架植入术+hUCM-SCs移植后8周CD34+(1.4±0.1)×109/L、CD31+(320±49)个/μl 和 CD14+CD16+(0.6±0.3)%。两组患者8周治疗后 CD34+、CD31+和CD14+CD16+水平之间有统计学差异( P<0.01)。结论人脐带间充质干细胞治疗老年人陈旧性心肌梗死较PCI+支架植入后CD34+水平增加,CD31+和CD14+CD16+水平降低,其可能参与了老年陈旧性心肌梗死患者细胞心肌成形术后心功能的恢复。
目的探討人臍帶間充質榦細胞治療老年人陳舊性心肌梗死的外週血CD34+、CD31+和CD14+CD16+錶達水平。方法採用流式細胞儀檢測經皮冠狀動脈介入治療( PCI )+支架植入術患者和PCI+支架植入術+人臍帶造血榦細胞( hUCM-SCs )移植術患者循環CD34+、CD31+和CD14+CD16+的錶達水平、心肌梗死麵積和左心室射血分數( LVEF)。評估CD34+、CD31+和CD14+CD16+對細胞心肌成形術早期預後的影響。結果兩組治療前各指標無統計學差異。 PCI +支架植入術後8週梗死麵積(26.6±3.4)%、LVEF(38.4±2.8)%;PCI+支架植入術+hUCM-SCs 移植後8週梗死麵積(24.2±3.9)%、LVEF (46.1±1.9)%,兩者比較均P<0.01。 PCI+支架植入術後8週CD34+(0.9±0.2)×109/L、CD31+(437±40)箇/μl和CD14+CD16+(0.9±0.2)%,PCI+支架植入術+hUCM-SCs移植後8週CD34+(1.4±0.1)×109/L、CD31+(320±49)箇/μl 和 CD14+CD16+(0.6±0.3)%。兩組患者8週治療後 CD34+、CD31+和CD14+CD16+水平之間有統計學差異( P<0.01)。結論人臍帶間充質榦細胞治療老年人陳舊性心肌梗死較PCI+支架植入後CD34+水平增加,CD31+和CD14+CD16+水平降低,其可能參與瞭老年陳舊性心肌梗死患者細胞心肌成形術後心功能的恢複。
목적탐토인제대간충질간세포치료노년인진구성심기경사적외주혈CD34+、CD31+화CD14+CD16+표체수평。방법채용류식세포의검측경피관상동맥개입치료( PCI )+지가식입술환자화PCI+지가식입술+인제대조혈간세포( hUCM-SCs )이식술환자순배CD34+、CD31+화CD14+CD16+적표체수평、심기경사면적화좌심실사혈분수( LVEF)。평고CD34+、CD31+화CD14+CD16+대세포심기성형술조기예후적영향。결과량조치료전각지표무통계학차이。 PCI +지가식입술후8주경사면적(26.6±3.4)%、LVEF(38.4±2.8)%;PCI+지가식입술+hUCM-SCs 이식후8주경사면적(24.2±3.9)%、LVEF (46.1±1.9)%,량자비교균P<0.01。 PCI+지가식입술후8주CD34+(0.9±0.2)×109/L、CD31+(437±40)개/μl화CD14+CD16+(0.9±0.2)%,PCI+지가식입술+hUCM-SCs이식후8주CD34+(1.4±0.1)×109/L、CD31+(320±49)개/μl 화 CD14+CD16+(0.6±0.3)%。량조환자8주치료후 CD34+、CD31+화CD14+CD16+수평지간유통계학차이( P<0.01)。결론인제대간충질간세포치료노년인진구성심기경사교PCI+지가식입후CD34+수평증가,CD31+화CD14+CD16+수평강저,기가능삼여료노년진구성심기경사환자세포심기성형술후심공능적회복。
Objective To study the effects of peripheral blood CD 34 +, CD31 +and CD14 +CD16 + on human umbilical cord mesenchymal stem cells (hUCM-SCs)transplantation in patients with old myocardial infarction . Methods The expressions of circulating CD 34 +,CD31 +and CD14 +CD16 +in elderly patients with coronary stent implantation and cellular cardiomyoplasty were measured by flow cytometry to observe the effects of levels in CD 34 +, CD31 +and CD14 +CD16 +on infarct size and left ventricular ejection fraction (LVEF).Results At eight weeks, there were significant difference between CD 34 +, CD31 +and CD14 +CD16 + of patients with coronary stent implantation and patients with hUCM-SCs transplantation:infarct size ( 26.6 ±3.4 )% vs.( 24.2 ±3.9 )%, P <0.01;LVEF(38.4 ±2.8)%vs.(46.1 ±1.9)%,P<0.01.CD34 +(0.9 ±0.2) ×109/L vs.(1.4 ±0.1) ×109/L, CD31 +(437 ±40)/μl vs.(320 ±49)/μl and CD14 +CD16 +(0.9 ±0.2)% vs.(0.6 ±0.3)%,all P<0.01. Conclusions Levels of CD34 +, CD31 +and CD14 +CD16 +may affect the hUCM-SCs transplantation in patients with old myocardial infarction .