CAJ | 학술논문

目的探求可以预测感染性心内膜炎患者住院期间总栓塞事件的独立因素。方法回顾性分析南京鼓楼医院2005～2012年收治的133例感染性心内膜炎患者的发病特点，包括基本情况、生化结果、超声心动图表现和血培养结果与栓塞的关系。结果单因素分析发现WBC＞15×109/L、CRP＞40 mg/L、赘生物累及多个瓣膜以及赘生物大小＞1 cm与栓塞相关（ P值分别为0.023、0.029、0.004、＜0.001），将其纳入二元Logistic回归模型后发现赘生物累及多个瓣膜以及大小＞1 cm是栓塞的独立预测因素（ P＝0.003，OR＝3.34，95％CI：1.52～7.31；P＝0.030，OR＝2.37，95％CI：1.09～5.18）。结论赘生物累及多个瓣膜以及大小＞1 cm是栓塞的独立预测因素，临床中处理这类感染性心内膜炎患者时可能需尽早手术，以减少栓塞事件的发生。
목적탐구가이예측감염성심내막염환자주원기간총전새사건적독립인소。방법회고성분석남경고루의원2005～2012년수치적133례감염성심내막염환자적발병특점，포괄기본정황、생화결과、초성심동도표현화혈배양결과여전새적관계。결과단인소분석발현WBC＞15×109/L、CRP＞40 mg/L、췌생물루급다개판막이급췌생물대소＞1 cm여전새상관（ P치분별위0.023、0.029、0.004、＜0.001），장기납입이원Logistic회귀모형후발현췌생물루급다개판막이급대소＞1 cm시전새적독립예측인소（ P＝0.003，OR＝3.34，95％CI：1.52～7.31；P＝0.030，OR＝2.37，95％CI：1.09～5.18）。결론췌생물루급다개판막이급대소＞1 cm시전새적독립예측인소，림상중처리저류감염성심내막염환자시가능수진조수술，이감소전새사건적발생。
Objective To search the independent predictors of embolic events in patients with infective endocarditis.Methods 133 cases from Nanjing Gulou Hospital were collected during the year 2005 to 2012.Univariate and multivariate analyses were used to reveal the independent predictors of embolic events . Results White blood cell counts >15 ×109 /L,C-reactive protein >40 mg/L,multiple valve involvement andvegetation size >1 cm were associated with embolic events (P =0.023; P =0.029;P =0.004; P <0.001,respectively).Among them,multiple valve involvement and vegetation size >1 cm are independent predictors ofembolic events (P =0.003, OR =3.34,95% CI:1.52-7.31; P =0.030, OR =2.37,95% CI:1.09-5.18). Conclusions Multiple valve involvement and vegetation size >1 cm were independent predictors of embolic events .Identification of these factors should prompt consideration of early surgery .