中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
5期
1914-1917
,共4页
注意力缺陷障碍伴多动%盐酸托莫西汀%有效性和安全性
註意力缺陷障礙伴多動%鹽痠託莫西汀%有效性和安全性
주의력결함장애반다동%염산탁막서정%유효성화안전성
Attention deficit disorder with hyperactivity%Atomoxetine%Efficacy and safety
目的注意缺陷多动障碍（ ADHD）儿童服用盐酸托莫西汀治疗12周，评价其疗效和安全性。方法共110例ADHD儿童，口服盐酸托莫西汀治疗12周，在第0、4、8、12周，采用Swanson儿童行为量表第4版（ SNAP-Ⅳ）评分量表和第0和12周 Conners 父母问卷评估疗效，副反应量表评估用药安全性。结果 SNAP-Ⅳ量表显示评分在第4周、第8周、第12周与基线相比明显降低，且与基线相比有统计学差异（ P＜0.01）；在第12周时，Conners父母问卷评分与基线相比，6个观察因子（品行问题、学习问题、心身障碍、冲动-多动、焦虑、多动指数）评分均降低，且有统计学意义（ P＜0.01）。最多见的副反应是消化系统症状，发生率约为30％，主要表现为食欲减退或厌食；其次是神经系统症状，发生率为4.55％，但所有的副反应均为轻度或可疑。结论 ADHD儿童服用盐酸托莫西汀有效，起效较慢，无严重不良反应，使用安全，但要及时处理出现的药物不良反应，提高用药依从性。
目的註意缺陷多動障礙（ ADHD）兒童服用鹽痠託莫西汀治療12週，評價其療效和安全性。方法共110例ADHD兒童，口服鹽痠託莫西汀治療12週，在第0、4、8、12週，採用Swanson兒童行為量錶第4版（ SNAP-Ⅳ）評分量錶和第0和12週 Conners 父母問捲評估療效，副反應量錶評估用藥安全性。結果 SNAP-Ⅳ量錶顯示評分在第4週、第8週、第12週與基線相比明顯降低，且與基線相比有統計學差異（ P＜0.01）；在第12週時，Conners父母問捲評分與基線相比，6箇觀察因子（品行問題、學習問題、心身障礙、遲動-多動、焦慮、多動指數）評分均降低，且有統計學意義（ P＜0.01）。最多見的副反應是消化繫統癥狀，髮生率約為30％，主要錶現為食欲減退或厭食；其次是神經繫統癥狀，髮生率為4.55％，但所有的副反應均為輕度或可疑。結論 ADHD兒童服用鹽痠託莫西汀有效，起效較慢，無嚴重不良反應，使用安全，但要及時處理齣現的藥物不良反應，提高用藥依從性。
목적주의결함다동장애（ ADHD）인동복용염산탁막서정치료12주，평개기료효화안전성。방법공110례ADHD인동，구복염산탁막서정치료12주，재제0、4、8、12주，채용Swanson인동행위량표제4판（ SNAP-Ⅳ）평분량표화제0화12주 Conners 부모문권평고료효，부반응량표평고용약안전성。결과 SNAP-Ⅳ량표현시평분재제4주、제8주、제12주여기선상비명현강저，차여기선상비유통계학차이（ P＜0.01）；재제12주시，Conners부모문권평분여기선상비，6개관찰인자（품행문제、학습문제、심신장애、충동-다동、초필、다동지수）평분균강저，차유통계학의의（ P＜0.01）。최다견적부반응시소화계통증상，발생솔약위30％，주요표현위식욕감퇴혹염식；기차시신경계통증상，발생솔위4.55％，단소유적부반응균위경도혹가의。결론 ADHD인동복용염산탁막서정유효，기효교만，무엄중불량반응，사용안전，단요급시처리출현적약물불량반응，제고용약의종성。
Objective To evaluate the efficacy and safety after a 12-week treatment with atomoxetine hydrochloride(ATX)for the children with attention deficit hyperactivity disorder (ADHD).Methods For a total of 110 cases of the children with ADHD ,who were treated with oral ATX for 12 weeks,estimate the efficacy by using Swanson Child Behavior Scale Ⅳ(SNAP-Ⅳ) for the weeks of 0,4th,8th and 12th,and by using Conners Parents Questionnaire for the weeks of 0 and 12th;and assess the safety by using Treatment Emergent Symptom Scale (TESS).Results The scores of the SNAP-Ⅳfor the weeks of 4th,8th and 12th were significantly lower than the baseline,and the difference was statistically significant (P<0.01).The score of Conners Parents Questionnaire for the week of 12th was lower than the baseline and statistically significant (P <0.01),for all 6 observing factors, including morality problem , study problem , psychosomatic disorder , impulse-hyperactivity , anxiety and hyperactive index.The most common side effect was the gastrointestinal symptoms with an incidence rate of about 30%,mainly appeared with anorexia or apocleisis;the secondly common side effect was neurological symptoms with an incidence rate of 4.55%.But all these side effects were mild or doubtable .Conclusions This study shows that it′s effective for the ADHD children to be treated with ATX ,although ATX works slowly ,it′s also safe ,and no serious adverse even occurred.However,the drug adverse reaction should be taken care in time to improve the compliance .
