CAJ | 학술논문

目的检测重症肌无力患者血清白细胞介素（ IL）-17、21、23的表达水平，探讨IL-17、IL-21和IL-23水平与重症肌无力发病的关系。方法采用酶联免疫分析法检测45例重症肌无力患者血清IL-17、IL-21和IL-23水平，并与正常对照组比较。结果重症肌无力组IL-17、IL-21和IL-23水平高于对照组（重症肌无力组IL-17、IL-21和IL-23中位数分别为5.86 pg/ml、198.15 pg/ml、224.04 pg/ml，对照组中位数分别为5.20 pg/ml、80.27 pg/ml、59.46 pg/ml），差异具有统计学意义（ P＜0.05）。眼肌型与全身型相比IL-17、IL-21、IL-23水平无显著性差异（ P＞0.05）。胸腺疾病组与非胸腺疾病组IL-17、IL-21、IL-23水平无显著性差异（ P＞0.05）。结论 IL-17、IL-21和IL-23在重症肌无力发病的免疫调节过程中发挥一定作用。
목적검측중증기무력환자혈청백세포개소（ IL）-17、21、23적표체수평，탐토IL-17、IL-21화IL-23수평여중증기무력발병적관계。방법채용매련면역분석법검측45례중증기무력환자혈청IL-17、IL-21화IL-23수평，병여정상대조조비교。결과중증기무력조IL-17、IL-21화IL-23수평고우대조조（중증기무력조IL-17、IL-21화IL-23중위수분별위5.86 pg/ml、198.15 pg/ml、224.04 pg/ml，대조조중위수분별위5.20 pg/ml、80.27 pg/ml、59.46 pg/ml），차이구유통계학의의（ P＜0.05）。안기형여전신형상비IL-17、IL-21、IL-23수평무현저성차이（ P＞0.05）。흉선질병조여비흉선질병조IL-17、IL-21、IL-23수평무현저성차이（ P＞0.05）。결론 IL-17、IL-21화IL-23재중증기무력발병적면역조절과정중발휘일정작용。
Objective To understand the relationship between interleukin ( IL)-17,21 and 23 and MG pathogenesis by detecting the expression level on serum IL-17,IL-21 and IL-23 of MG patients.Methods We detected the level of serum IL-17, IL-21 and IL-23 by applying EIA ( enzyme immunoassay ) for MG patients. Results The study data showed that there was a significantly differences between the MG group and the control group for the expression levels on IL-17,IL-21 and IL-23(P<0.05),but there was no relationship in the expression levels on IL-17,IL-21 and IL-23 between the ocular type group and the generalized group (P>0.05).Grouped and counted by concomitant disease of thymus gland ,there was no distinct disperation in the expression levels on IL-17, IL-21 and IL-23 between the thymus gland group and contrast group ( P>0.05 ) .Conclusions Serum IL-17,IL-21 and IL-23 play a role in the process of immune regulation of MG pathogenesis .