CAJ | 학술논문

目的观察急性肝炎患者胃动素、生长素、胰高血糖素样肽-1的变化，并探讨急性肝炎患者胃动力异常的病理机制。方法石家庄市第一医院消化内一科2010年10月至2011年9月就诊的急性肝炎患者70例，其中男40例，女30例。健康志愿者35例，男20例，女15例。采用放射免疫法测定胃动素含量，酶联免疫法检测生长素和胰高血糖素样肽-1的血浆含量。结果胃动素水平急性肝炎组与对照组相比明显升高，差异有统计学意义（ P＜0.05）；急性黄疸型肝炎组胃动素升高水平较急性无黄疸型肝炎组显著，差异有统计学意义（P＜0.05）。生长素水平急性肝炎组与对照组相比明显升高，差异有统计学意义（P＜0.05）；急性黄疸型肝炎组较急性无黄疸型肝炎组升高，差异有统计学意义（ P＜0.05）。胰高血糖素样肽-1水平急性肝炎组与对照组相比明显升高，差异有统计学意义（ P＜0.05）；急性黄疸型肝炎较急性无黄疸型肝炎胰高血糖素样肽-1升高更显著，差异有统计学意义（ P＜0.05）。结论急性肝炎患者存在胃动素、生长素、胰高血糖素样肽-1分泌紊乱，可能与急性肝炎患者胃动力障碍有关。
목적관찰급성간염환자위동소、생장소、이고혈당소양태-1적변화，병탐토급성간염환자위동력이상적병리궤제。방법석가장시제일의원소화내일과2010년10월지2011년9월취진적급성간염환자70례，기중남40례，녀30례。건강지원자35례，남20례，녀15례。채용방사면역법측정위동소함량，매련면역법검측생장소화이고혈당소양태-1적혈장함량。결과위동소수평급성간염조여대조조상비명현승고，차이유통계학의의（ P＜0.05）；급성황달형간염조위동소승고수평교급성무황달형간염조현저，차이유통계학의의（P＜0.05）。생장소수평급성간염조여대조조상비명현승고，차이유통계학의의（P＜0.05）；급성황달형간염조교급성무황달형간염조승고，차이유통계학의의（ P＜0.05）。이고혈당소양태-1수평급성간염조여대조조상비명현승고，차이유통계학의의（ P＜0.05）；급성황달형간염교급성무황달형간염이고혈당소양태-1승고경현저，차이유통계학의의（ P＜0.05）。결론급성간염환자존재위동소、생장소、이고혈당소양태-1분비문란，가능여급성간염환자위동력장애유관。
Objective To observe the changes of Motilin(MTL),ghrelin,glucagon like peptide-1(GLP-1) in patients with acute hepatitis , and to investigate pathological mechanism of the abnormal gastric motility . Methods Acute hepatitis patients were 70 cases,from Shijiazhuang No 1 Hospital Department of Digestive 1,from October 2010 to September 2011,include 40 males and 30 females.Healthy cases 35,include 20 males and 15 females.The MTL,ghrelin and GLP-1 of all the patients and volunteers before the meal were detected .The level of plasma MTL were measured by radioimmunoassay and the level of plasma ghrelin and GLP-1 were measured by ELISA.Results MTL,ghrelin and GLP-1 in patients with acute hepatitis were abnormal .The level of MTL,ghrelin and GLP-1 in patients were higher than the control′s[(108.17 ±85.56)ng/ml vs.(55.02 ±16.84)ng/ml,(910.00 ±529.02)ng/ml vs.(803.62 ±399.47)ng/ml,(767.44 ±428.62)ng/ml vs.(473.63 ±197.88)ng/ml](P<0.05).Conclusions MTL,ghrelin and GLP-1 were abnormal in patients with acute hapatitis ,which maybe related with gastric motility disorder .