中华结直肠疾病电子杂志
中華結直腸疾病電子雜誌
중화결직장질병전자잡지
Chinese Journal of Colorectal Diseases
2014年
5期
22-24
,共3页
杨玉波%王斌%关铁军%闫光志%王晓明%陈峰%华南%周平%梁国栋%陈佳祺%刘海瑞%王首寒
楊玉波%王斌%關鐵軍%閆光誌%王曉明%陳峰%華南%週平%樑國棟%陳佳祺%劉海瑞%王首寒
양옥파%왕빈%관철군%염광지%왕효명%진봉%화남%주평%량국동%진가기%류해서%왕수한
结直肠肿瘤%免疫组织化学%AQP-5
結直腸腫瘤%免疫組織化學%AQP-5
결직장종류%면역조직화학%AQP-5
Colorectal carcinoma%Immunohistochemistry%AQP-5
目的：探讨结直肠癌组织中AQP-5的表达情况及其与肿瘤分化程度的关系。方法收集48例结直肠癌病变的石蜡包埋标本（结肠癌17例，直肠癌31例），采用免疫组织化学S-P方法检测AQP-5在上述病变组织中的表达。结果结肠癌组织中癌细胞AQP-5（＋）表达率为64．7％（11/17），其中高、中分化癌组织病例中，呈阳性者3例，阳性率为33．3％，而8例低分化病例中，阳性8例，阳性率为100．0％，二者表达差异显著（ P＜0．01）。直肠癌病变中癌细胞AQP-5（＋）表达率为70．9％（22/31），13例高中分化病例中，阳性者6例，阳性率46．2％，18例低分化病例中16例呈阳性，阳性率为88．8％，二者具有差异（P＜0．05）；两种类型肠癌CD10表达无统计学差异（P＞0．05）。结论 AQP-5有助于显示结直肠癌的分化程度，对选择治疗方案及判断预后有一定意义。
目的：探討結直腸癌組織中AQP-5的錶達情況及其與腫瘤分化程度的關繫。方法收集48例結直腸癌病變的石蠟包埋標本（結腸癌17例，直腸癌31例），採用免疫組織化學S-P方法檢測AQP-5在上述病變組織中的錶達。結果結腸癌組織中癌細胞AQP-5（＋）錶達率為64．7％（11/17），其中高、中分化癌組織病例中，呈暘性者3例，暘性率為33．3％，而8例低分化病例中，暘性8例，暘性率為100．0％，二者錶達差異顯著（ P＜0．01）。直腸癌病變中癌細胞AQP-5（＋）錶達率為70．9％（22/31），13例高中分化病例中，暘性者6例，暘性率46．2％，18例低分化病例中16例呈暘性，暘性率為88．8％，二者具有差異（P＜0．05）；兩種類型腸癌CD10錶達無統計學差異（P＞0．05）。結論 AQP-5有助于顯示結直腸癌的分化程度，對選擇治療方案及判斷預後有一定意義。
목적：탐토결직장암조직중AQP-5적표체정황급기여종류분화정도적관계。방법수집48례결직장암병변적석사포매표본（결장암17례，직장암31례），채용면역조직화학S-P방법검측AQP-5재상술병변조직중적표체。결과결장암조직중암세포AQP-5（＋）표체솔위64．7％（11/17），기중고、중분화암조직병례중，정양성자3례，양성솔위33．3％，이8례저분화병례중，양성8례，양성솔위100．0％，이자표체차이현저（ P＜0．01）。직장암병변중암세포AQP-5（＋）표체솔위70．9％（22/31），13례고중분화병례중，양성자6례，양성솔46．2％，18례저분화병례중16례정양성，양성솔위88．8％，이자구유차이（P＜0．05）；량충류형장암CD10표체무통계학차이（P＞0．05）。결론 AQP-5유조우현시결직장암적분화정도，대선택치료방안급판단예후유일정의의。
Objective To analyze the expression of AQP-5 in colorectal carcinoma ,and to explore the relationship between AQP-5 expression and differentiation of the tumor .Methods 48 cases of colorectal carcinoma samples were collected ,including 17 cases of colon carcinoma and 31 cases of rectum carcinoma . Expression of AQP-5 was detected by immunohistochemical s-p method.Results The positive expression rate of AQP-5 of carcinoma cells in colon carcinoma was 64.7%( 11/17 ).In well-and moderately-differentiated carcinoma groups,the positive expression rate was 33.3%(3/9),however,that in poorly carcinoma was 100.0%(8/8),which showed difference between two groups (P <0.01).The positive expression rate of AQP-5 of carcinoma cells in rectum carcinoma was 70.9%( 22/31 ).In well-and moderately-differentiated carcinoma groups ,AQP-5 was expressed in 6 cases,with a positive rate of 46.2%, that in poorly carcinoma was 88.8%( 16/18 ), there was statistically difference ( P <0.05 );AQP-5 expression was not different in two types of carcinoma (P>0.05).Conclusion AQP-5 seems to be a highly effective marker for differentiation in colon and rectum carcinoma , it may be very helpful to make the best choice of treatment and prognosis .
