CAJ | 학술논문

目的：观察马来酸桂哌齐特注射液联合复方丹参注射液治疗结肠慢传输型便秘的临床疗效。方法选取42例结肠慢传输型便秘患者作为研究对象，给予马来酸桂哌齐特注射液8 ml加入0．9％生理盐水500 ml静脉滴注，每天1次，疗程14 d；复方丹参注射液20 ml加入0．9％生理盐水250 ml静脉滴注，每天1次，疗程14 d。观察治疗前后的症状积分、肠内不透X线标记物残留情况及不良反应。结果用药14 d后Bristol评分较治疗前有显著降低，差异有统计学意义（P＜0．05），治疗后患者肠内残留标记物数较治疗前显著减少，差异有统计学意义（P ＜0．05），治疗总有效率78．25％，无明显不良反应。结论马来酸桂哌齐特注射液联合复方丹参注射液治疗结肠慢传输型便秘临床疗效显著，可以改善肠道微循环，可能降低肠道血管阻力，增加血流量，促进肠蠕动，增强肠动力传输。
목적：관찰마래산계고제특주사액연합복방단삼주사액치료결장만전수형편비적림상료효。방법선취42례결장만전수형편비환자작위연구대상，급여마래산계고제특주사액8 ml가입0．9％생리염수500 ml정맥적주，매천1차，료정14 d；복방단삼주사액20 ml가입0．9％생리염수250 ml정맥적주，매천1차，료정14 d。관찰치료전후적증상적분、장내불투X선표기물잔류정황급불량반응。결과용약14 d후Bristol평분교치료전유현저강저，차이유통계학의의（P＜0．05），치료후환자장내잔류표기물수교치료전현저감소，차이유통계학의의（P ＜0．05），치료총유효솔78．25％，무명현불량반응。결론마래산계고제특주사액연합복방단삼주사액치료결장만전수형편비림상료효현저，가이개선장도미순배，가능강저장도혈관조력，증가혈류량，촉진장연동，증강장동력전수。
Objective To observe the clinical effects of Cinepazide Maleate and compound danshen injection on treating slow transit constipation .Method 42 cases of slow transit constipation were selected and injected with Cinepazide Maleate once a day and for 14 days as a treatment cycle .The symptoms, impervious X-ray marker residue and adverse reactions were observed before and after the treatment .Results After 14 days,Bristol score was significantly lower after treatment ,the difference was statistically significant (P<0.05),intestinal residue markers was significantly reduced than before ,the difference was statistically significant(P<0.05).The total effective rate was 78.25%,and there was no obvious adverse reaction . Conclusion Cinepazide Maleate and danshen compound injection had significantly clinical effects on treating slow transit constipation by improving the intestinal microcirculation ,reducing the intestinal vascular resistance ,increasing blood flow ,promoting intestinal peristalsis and enhancing bowel power transmission .