CAJ | 학술논문

目的：探讨胰岛素样生长因子结合蛋白-6(IGFBP-6)在乳腺癌组织中的表达及其与乳腺癌临床病理特征的关系。方法：采用免疫组织化学SP法检测60例乳腺癌、30例乳腺纤维腺瘤、20例乳腺增生症组织IGFBP-6的表达。结果：乳腺癌、乳腺纤维腺瘤和乳腺增生症组织中IGFBP-6表达水平不同(P＜0.05)。乳腺癌组织IGFBP-6的表达与年龄、组织学类型无关(P＞0.05)，与肿瘤大小及淋巴结转移有关(P＜0.05)。结论：IGFBP-6可能在乳腺癌的发生发展过程中具有重要作用。
목적：탐토이도소양생장인자결합단백-6(IGFBP-6)재유선암조직중적표체급기여유선암림상병리특정적관계。방법：채용면역조직화학SP법검측60례유선암、30례유선섬유선류、20례유선증생증조직IGFBP-6적표체。결과：유선암、유선섬유선류화유선증생증조직중IGFBP-6표체수평불동(P＜0.05)。유선암조직IGFBP-6적표체여년령、조직학류형무관(P＞0.05)，여종류대소급림파결전이유관(P＜0.05)。결론：IGFBP-6가능재유선암적발생발전과정중구유중요작용。
Objective:To investigate the expression of insulin-like growth factor binding protein-6 (IGFBP-6) in breast cancer, and the relationship between IGFBP-6 expression and clinicopathological features of breast cancer. Methods:SP immunohistochemical staining was used to detect the IGFBP-6 expression in 60 cases breast cancer, 30 cases breast ifbroadenoma and 20 cases cyclomastopathy.Results:The expression of IGFBP-6 expression in breast cancer, breast ifbroadenoma and cyclomastopathy was different (P<0.05). In breast cancer, the IGFBP-6 expression had no relations with age and histological type (P>0.05);but was related to size of tumor and lymph node (P<0.05). Conclusions:IGFBP-6 may play important role in development of breast cancer.