CAJ | 학술논문

目的研究a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗糖尿病周围神经病变60例临床疗效.方法选择2012年3月至2012年9月我院收治的60例糖尿病周围神经病变患者,按照随机数表法分为A组和B组两组.每组各30例.A组采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)三药联合用药进行治疗；B组采用甲钴胺(弥可宝)、前列地尔(凯时)两药联合进行治疗.治疗2周后,对两组患者的治疗临床疗效以及治疗后两组患者的神经传导速度进行比较分析.结果 A组治疗的总有效率为86.7％,B组治疗的总有效率为66.7％,A组治疗的临床效果明显优于B组(P＜0.05);治疗后,两组患者的神经传导速度均出现明显改善,但是采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗的A组,较采用甲钴胺(弥可宝)、前列地尔(凯时)联合治疗的B组改善效果更明显(P＜0.05).结论采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗糖尿病周围神经病变临床效果显著,可明显增加患者神经传导速度,值得临床推广应用.
목적 연구a-류신산(국산)、갑고알(미가보)、전렬지이(개시)연합치료당뇨병주위신경병변60례림상료효.방법 선택2012년3월지2012년9월아원수치적60례당뇨병주위신경병변환자,안조수궤수표법분위A조화B조량조.매조각30례.A조채용a-류신산(국산)、갑고알(미가보)、전렬지이(개시)삼약연합용약진행치료；B조채용갑고알(미가보)、전렬지이(개시)량약연합진행치료.치료2주후,대량조환자적치료림상료효이급치료후량조환자적신경전도속도진행비교분석.결과 A조치료적총유효솔위86.7％,B조치료적총유효솔위66.7％,A조치료적림상효과명현우우B조(P＜0.05);치료후,량조환자적신경전도속도균출현명현개선,단시채용a-류신산(국산)、갑고알(미가보)、전렬지이(개시)연합치료적A조,교채용갑고알(미가보)、전렬지이(개시)연합치료적B조개선효과경명현(P＜0.05).결론 채용a-류신산(국산)、갑고알(미가보)、전렬지이(개시)연합치료당뇨병주위신경병변림상효과현저,가명현증가환자신경전도속도,치득림상추엄응용.
Objective To study the clinical curative effect of α-lipoic acid (domestic) combined with the mMethylcobalamin and alprostadil combination therapy to 60 cases of diabetic peripheral neuropathy.Methods The 60 patients with diabetic peripheral neuropathy from March 2009 to March 2011 were divided into group A and group B,according to the random number table method,30 patients in each group.Group A used α-lipoic acid (domestic) combined with methylcobalamin and alprostadil three-drug combination treatment; group B used the methylcobalamin and alprostadil the two-drug combination treatment.After two weeks of treatment,the clinical efficacy of treatment as well as nerve conduction velocity in patients of the two groups were compared.Results Total effective rate of group A was 86.7％,B group was 66.7％,the clinical effect of the group A was significantly better than that of the group B (P＜0.05); nerve conduction velocity after treatment also showed significant improvement,but the clinical effects of group A was more obvious than group B (P＜0.05).Conclusions The effect of α-lipoic acid (domestic) combined with the methylcobalamin and alprostadil for diabetic peripheral neuropathy treatment is significant,the nerve conduction velocity of patients is significantly increased,worthy of clinical application.