CAJ | 학술논문

目的：探讨急性冠脉综合征（ACS）患者血清卵泡抑素样蛋白1（FSTL-1）水平变化的意义。方法：ACS患者205例，依据ACC/AHA指南进行危险分层，分为低危组59例，中危组69例，高危组77例。选取同期非缺血性胸痛患者50例作对照。采用ELISA法测定血清FSTL-1水平，采用Gensini评分系统评测冠脉病变严重程度，同时测定血脂、肌钙蛋白T（cTnT）和N末端B型利钠肽原（NT-proBNP）等指标。结果：高危组、中危组、低危组及对照组4组间血清FSTL-1水平差异有统计学意义（F＝311．588，P＜0．001），从高危组、中危组到低危组血清FSTL-1水平逐渐降低（P＜0．05），但均高于对照组（P＜0．05）。高危组和中危组ACS患者血清FSTL-1水平与Gensini评分、血清NT-proBNP水平呈线性正相关（r＝0．756、0．465和0．699、0．395， P均＜0．01）。结论：血清FSTL-1水平有可能成为评估早期ACS病变严重程度的生物标志物。
목적：탐토급성관맥종합정（ACS）환자혈청란포억소양단백1（FSTL-1）수평변화적의의。방법：ACS환자205례，의거ACC/AHA지남진행위험분층，분위저위조59례，중위조69례，고위조77례。선취동기비결혈성흉통환자50례작대조。채용ELISA법측정혈청FSTL-1수평，채용Gensini평분계통평측관맥병변엄중정도，동시측정혈지、기개단백T（cTnT）화N말단B형리납태원（NT-proBNP）등지표。결과：고위조、중위조、저위조급대조조4조간혈청FSTL-1수평차이유통계학의의（F＝311．588，P＜0．001），종고위조、중위조도저위조혈청FSTL-1수평축점강저（P＜0．05），단균고우대조조（P＜0．05）。고위조화중위조ACS환자혈청FSTL-1수평여Gensini평분、혈청NT-proBNP수평정선성정상관（r＝0．756、0．465화0．699、0．395， P균＜0．01）。결론：혈청FSTL-1수평유가능성위평고조기ACS병변엄중정도적생물표지물。
Aim:To explore the relationship between the serum level of follistatin-like protein 1(FSTL-1) and the se-verity of coronary artery disease in patients with acute coronary syndrome ( ACS) .Methods:A total of 205 patients of ACS were divided into three groups according to ACC /AHA guide,the low-risk group(n=59),the middle-risk group(n=69) and the high-risk group ( n=77 ) , and 50 individuals without ischemic chest pain were the control .The serum level of FSTL-1 was examined by ELISA .The degree of coronary artery stenosis was assessed by Gensini score .The serum lipids , cardiac troponin T ( cTnT ) and N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) were detected .Results: There were significant differences in the serum level of FSTL-1 among the 4 groups(F=311.588,P<0.001).Compared with the control group, the serum level of FSTL-1 of ACS patients were higher , and decreased from the high-risk group, the middle-risk group to the low-risk group(P<0.05).In the high-risk group, the correlation of the serum level of FSTL-1 to Gensini score and serum NT-proBNP level were positive (r=0.756 and 0.465, P<0.01),and the same with the middle-risk group (r=0.699 and 0.395, P<0.01).Conclusion:The serum level of FSTL-1 may be a useful early biomarker for assessing severity degree of ACS .