郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2013年
5期
605-609
,共5页
胶质瘤%胞质多聚腺苷酸化成分结合蛋白4%Bcl-xL%预后
膠質瘤%胞質多聚腺苷痠化成分結閤蛋白4%Bcl-xL%預後
효질류%포질다취선감산화성분결합단백4%Bcl-xL%예후
glioma%cytoplasmic polyadenylation element-binding protein 4%Bcl-xL%prognosis
目的:检测胞质多聚腺苷酸化成分结合蛋白4(CPEB4)和Bcl-xL在胶质瘤组织中的表达,并探讨二者及多种临床病理因素与患者预后的关系。方法:应用免疫组化染色检测165例不同级别胶质瘤(低级别69例,高级别96例)组织中CPEB4和Bcl-xL的表达情况,采用logistic回归分析探讨影响胶质瘤预后的危险因素。结果:高级别胶质瘤组织中CPEB4和Bcl-xL的阳性表达率均高于低级别胶质瘤组织(χ2=28.971和17.601,P<0.05)。单因素分析显示,患者术前KPS评分、肿瘤直径、肿瘤切除范围、术后放疗、术后化疗、病理级别、CPEB4和Bcl-xL的表达对3 a生存率有影响(P<0.05),构建的判别函数判别符合率达90.9%;多因素分析表明,术前KPS评分、肿瘤切除范围、术后化疗、病理级别、CPEB4和Bcl-xL的表达是影响胶质瘤患者3 a生存率的独立因素(P<0.05),判别函数Y=-0.644+1.386 X3+1.052 X5+1.248 X6-2.679 X10-1.042 X11-2.659 X12,判别符合率达88.3%。结论:CPEB4和Bcl-xL阳性表达与胶质瘤恶性程度有关;术前KPS评分、肿瘤切除范围、术后化疗、病理级别、CPEB4和Bcl-xL的表达可作为考察胶质瘤患者预后情况的重要指标。
目的:檢測胞質多聚腺苷痠化成分結閤蛋白4(CPEB4)和Bcl-xL在膠質瘤組織中的錶達,併探討二者及多種臨床病理因素與患者預後的關繫。方法:應用免疫組化染色檢測165例不同級彆膠質瘤(低級彆69例,高級彆96例)組織中CPEB4和Bcl-xL的錶達情況,採用logistic迴歸分析探討影響膠質瘤預後的危險因素。結果:高級彆膠質瘤組織中CPEB4和Bcl-xL的暘性錶達率均高于低級彆膠質瘤組織(χ2=28.971和17.601,P<0.05)。單因素分析顯示,患者術前KPS評分、腫瘤直徑、腫瘤切除範圍、術後放療、術後化療、病理級彆、CPEB4和Bcl-xL的錶達對3 a生存率有影響(P<0.05),構建的判彆函數判彆符閤率達90.9%;多因素分析錶明,術前KPS評分、腫瘤切除範圍、術後化療、病理級彆、CPEB4和Bcl-xL的錶達是影響膠質瘤患者3 a生存率的獨立因素(P<0.05),判彆函數Y=-0.644+1.386 X3+1.052 X5+1.248 X6-2.679 X10-1.042 X11-2.659 X12,判彆符閤率達88.3%。結論:CPEB4和Bcl-xL暘性錶達與膠質瘤噁性程度有關;術前KPS評分、腫瘤切除範圍、術後化療、病理級彆、CPEB4和Bcl-xL的錶達可作為攷察膠質瘤患者預後情況的重要指標。
목적:검측포질다취선감산화성분결합단백4(CPEB4)화Bcl-xL재효질류조직중적표체,병탐토이자급다충림상병리인소여환자예후적관계。방법:응용면역조화염색검측165례불동급별효질류(저급별69례,고급별96례)조직중CPEB4화Bcl-xL적표체정황,채용logistic회귀분석탐토영향효질류예후적위험인소。결과:고급별효질류조직중CPEB4화Bcl-xL적양성표체솔균고우저급별효질류조직(χ2=28.971화17.601,P<0.05)。단인소분석현시,환자술전KPS평분、종류직경、종류절제범위、술후방료、술후화료、병리급별、CPEB4화Bcl-xL적표체대3 a생존솔유영향(P<0.05),구건적판별함수판별부합솔체90.9%;다인소분석표명,술전KPS평분、종류절제범위、술후화료、병리급별、CPEB4화Bcl-xL적표체시영향효질류환자3 a생존솔적독립인소(P<0.05),판별함수Y=-0.644+1.386 X3+1.052 X5+1.248 X6-2.679 X10-1.042 X11-2.659 X12,판별부합솔체88.3%。결론:CPEB4화Bcl-xL양성표체여효질류악성정도유관;술전KPS평분、종류절제범위、술후화료、병리급별、CPEB4화Bcl-xL적표체가작위고찰효질류환자예후정황적중요지표。
Aim:To detect the expressions of cytoplasmic polyadenylation element-binding protein 4 ( CPEB4 ) and Bcl-xL in glioma tissue , and investigate the prognostic factors of patients with glioma .Methods:The expressions of CPEB 4 and Bcl-xL in 165 cases of different grade glioma (69 cases of low grade , and 96 cases of high grade ) tissue were detected by immunohistochemical staining .The univariate and multivariate logistic regression was used to analyze the relationship between the expressions of CPEB 4 and Bcl-xL and the clinical factors with 3-year survival rate of the patients .Results:The positive expression rates of CPEB 4 and Bcl-xL in high grade glioma were significantly higher than those in low grade glioma(χ2 =28.971 and 17.601,P<0.05).The univariate logistic regression analysis screened 8 related factors(P<0.05),among which, multivariate logistic regression analysis further screened 6 independent factors including preoperative KPS score, the resection extent , postoperative chemotherapy , malignant degree and the expressions of CPEB 4 and Bcl-xL (P<0.05).Conclusion:The expressions of CPEB4 and Bcl-xL are related with the malignant degree of glioma .The pre-operative KPS score , the resection extent , postoperative chemotherapy , malignant degree and the expressions of CPEB 4 and Bcl-xL can be regarded as important prognostic indicators for patients with glioma .