CAJ | 학술논문

目的：探讨雌激素受体（ ER）α基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的关系。方法：将2002年至2012年国内外发表的ERα基因PvuⅡrs2234693多态性与乳癌关系相关的文献进行检索，并进行异质性检验，计算OR值（95％CI）。结果：符合纳入标准的共有14篇文献，累计乳癌病例10755例，对照17074例。与野生纯合基因型TT相比，CC突变基因型异质性检验P＝0．03，OR（95％CI）为0．91（0．81～1．02）；CT杂合型及CC＋CT联合型的异质性检验P分别为0．57、0．44，OR（95％CI）分别为0．96（0．90～1．02）、0．94（0．89～1．00）。结论：未发现ERα基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的相关性。
목적：탐토자격소수체（ ER）α기인PvuⅡrs2234693위점다태성여유암발병풍험지간적관계。방법：장2002년지2012년국내외발표적ERα기인PvuⅡrs2234693다태성여유암관계상관적문헌진행검색，병진행이질성검험，계산OR치（95％CI）。결과：부합납입표준적공유14편문헌，루계유암병례10755례，대조17074례。여야생순합기인형TT상비，CC돌변기인형이질성검험P＝0．03，OR（95％CI）위0．91（0．81～1．02）；CT잡합형급CC＋CT연합형적이질성검험P분별위0．57、0．44，OR（95％CI）분별위0．96（0．90～1．02）、0．94（0．89～1．00）。결론：미발현ERα기인PvuⅡrs2234693위점다태성여유암발병풍험지간적상관성。
Aim:To explore the relationship between PvuⅡrs2234693 polymorphisms in estrogen receptor α( ERα) and risk of breast cancer occurrence .Methods: All literatures related to PvuⅡrs2234693 polymorphisms in ERαand breast cancer which published openly between 2002 and 2012 were reviewed .Heterogeneity test for each research data was performed and OR(95%CI) was analyzed.Results:There were 14 literatures conformed to the inclusion criteria .A total of 10 755 breast cancer cases and 17 074 controls were included .The meta-analysis showed that compared with the wild-type homozygous TT, the P of heterogeneity test for CC variant genotype was 0.03, and OR(95%CI) was 0.91(0.81-1.02).The P of heterogeneity test for CT heterozygous and CC +CT joint type was 0.57, 0.44, and OR(95%CI) was 0.96(0.90-1.02), 0.94(0.89-1.00).Conclusion: No relationship between the genotype of PvuⅡrs2234693 poly-morphisms in ERαand risk of breast cancer occurrence is found .