中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
1期
61-63
,共3页
酒精性肝炎%病毒性肝炎%肝硬化%临床表现
酒精性肝炎%病毒性肝炎%肝硬化%臨床錶現
주정성간염%병독성간염%간경화%림상표현
Alcoholic hepatitis%Viral hepatitis%Liver cirrhosis%Clinical manifestations
目的 分析酒精性肝硬化(AC)与肝炎后肝硬化(VC)的发病人群特征及临床表现的差异.方法 回顾性分析山东省滨州市人民医院收治的AC(70例)与VC(300例)患者的临床资料,比较两组患者性别、年龄、病程及肝硬化临床表现及天冬氨酸氨基转移酶/丙氨酸氨基转移酶(AST/ALT)、γ谷氨酰转肽酶(γ-GT)、碱性磷酸酶(ALP)与总胆红素(TBil)的差异.结果 AC组男性比例为91.43％(64/70),显著高于VC组64％ (192/300)(x2=15.76,P=0.003);AC组的平均年龄和病程分别为(50.13 ±12.35)岁和(2.09±0.67)年,显著低于VC组的(58.66±7.45)岁和(4.56±1.14)年(=3.97,P =0.042;t=5.22,P=0.034);两组患者间肝功能分级比较差异无统计学意义(P＞0.05);肝功能退行性表现中AC组患者鼻出血(18.57％)、齿龈出血(27.14％)、肝掌(64.29％)、蜘蛛痣(45.71％)的比例显著高于VC组(6.33％、15.00％、47.00％、29.67％),其P值分别为0.017、0.036、0.025、0.016;门脉高压表现中AC组脾大(81.43％)、食管胃底静脉曲张(65.71％)的发病率显著低于VC组(90.33％、86.00％),其P值分别为0.037和0.011;肝硬化的实验室检查指标结果显示AC组患者的AST/ALT比值、γ-GT、ALP分别为1.97±0.45、(152.33±23.41) U/L和(232.46±35.16) U/L,显著高于VC组的1.00±0.22、(45.89±11.23) U/L及(102.23±21.78) U/L,其P值分别为0.035、0.011及0.007.结论 AC与VC发病人群特征不同,临床表现和实验室指标亦存在着差异.
目的 分析酒精性肝硬化(AC)與肝炎後肝硬化(VC)的髮病人群特徵及臨床錶現的差異.方法 迴顧性分析山東省濱州市人民醫院收治的AC(70例)與VC(300例)患者的臨床資料,比較兩組患者性彆、年齡、病程及肝硬化臨床錶現及天鼕氨痠氨基轉移酶/丙氨痠氨基轉移酶(AST/ALT)、γ穀氨酰轉肽酶(γ-GT)、堿性燐痠酶(ALP)與總膽紅素(TBil)的差異.結果 AC組男性比例為91.43％(64/70),顯著高于VC組64％ (192/300)(x2=15.76,P=0.003);AC組的平均年齡和病程分彆為(50.13 ±12.35)歲和(2.09±0.67)年,顯著低于VC組的(58.66±7.45)歲和(4.56±1.14)年(=3.97,P =0.042;t=5.22,P=0.034);兩組患者間肝功能分級比較差異無統計學意義(P＞0.05);肝功能退行性錶現中AC組患者鼻齣血(18.57％)、齒齦齣血(27.14％)、肝掌(64.29％)、蜘蛛痣(45.71％)的比例顯著高于VC組(6.33％、15.00％、47.00％、29.67％),其P值分彆為0.017、0.036、0.025、0.016;門脈高壓錶現中AC組脾大(81.43％)、食管胃底靜脈麯張(65.71％)的髮病率顯著低于VC組(90.33％、86.00％),其P值分彆為0.037和0.011;肝硬化的實驗室檢查指標結果顯示AC組患者的AST/ALT比值、γ-GT、ALP分彆為1.97±0.45、(152.33±23.41) U/L和(232.46±35.16) U/L,顯著高于VC組的1.00±0.22、(45.89±11.23) U/L及(102.23±21.78) U/L,其P值分彆為0.035、0.011及0.007.結論 AC與VC髮病人群特徵不同,臨床錶現和實驗室指標亦存在著差異.
목적 분석주정성간경화(AC)여간염후간경화(VC)적발병인군특정급림상표현적차이.방법 회고성분석산동성빈주시인민의원수치적AC(70례)여VC(300례)환자적림상자료,비교량조환자성별、년령、병정급간경화림상표현급천동안산안기전이매/병안산안기전이매(AST/ALT)、γ곡안선전태매(γ-GT)、감성린산매(ALP)여총담홍소(TBil)적차이.결과 AC조남성비례위91.43％(64/70),현저고우VC조64％ (192/300)(x2=15.76,P=0.003);AC조적평균년령화병정분별위(50.13 ±12.35)세화(2.09±0.67)년,현저저우VC조적(58.66±7.45)세화(4.56±1.14)년(=3.97,P =0.042;t=5.22,P=0.034);량조환자간간공능분급비교차이무통계학의의(P＞0.05);간공능퇴행성표현중AC조환자비출혈(18.57％)、치간출혈(27.14％)、간장(64.29％)、지주지(45.71％)적비례현저고우VC조(6.33％、15.00％、47.00％、29.67％),기P치분별위0.017、0.036、0.025、0.016;문맥고압표현중AC조비대(81.43％)、식관위저정맥곡장(65.71％)적발병솔현저저우VC조(90.33％、86.00％),기P치분별위0.037화0.011;간경화적실험실검사지표결과현시AC조환자적AST/ALT비치、γ-GT、ALP분별위1.97±0.45、(152.33±23.41) U/L화(232.46±35.16) U/L,현저고우VC조적1.00±0.22、(45.89±11.23) U/L급(102.23±21.78) U/L,기P치분별위0.035、0.011급0.007.결론 AC여VC발병인군특정불동,림상표현화실험실지표역존재착차이.
Objective To investigate the differences of the characteristic and syndrome of patients with alcoholic cirrhosis(AC) and viral cirrhosis(VC).Methods Seventy patients with AC and 300 patients with VC in the Binzhou People's Hospital were selected as our subjects.The information including gender,age,disease history,chnical syndrome were collected.Meanwhile,the levels of Aspartate aminotransferase/alanine aminotransferase (AST/ALT),γ-glutamyl transferase (γ-GT),alkaline phosphatase (ALP) and total bilirubin (TBil) in serum were measured.Results The proportion of males in the AC group was 91.43％ (64/70),significantly higher than that of VC group(64％ (192/300),x2 =15.76,P =0.003)).The age,disease periods in AC group were (50.13 ± 12.35) years old and (2.09 ± 0.67) years,lower than the VC group ((58.66 ± 7.45) yearsold,t =3.97,P =0.042 ; (4.56 ± 1.14) years,t =5.22,P =0.034).There was no significant difference regarding of liver function index (P ＞ 0.05).The rate of nasal carp (18.57％),gum bleeding (27.14％),liver palms(64.29％),spider(45.71％) in the AC group were significantly higher than the VC group (6.33％,15.00％,47.00％,29.67％ respectively,P =0.017,0.036,0.025,0.016 respectively).The ratio of splenomegaly and esophageal varices were (81.43％) and (65.71％) in AC group,significantly lower than VC group (90.33％,86.00％ respectively,P =0.037,0.011 respectively).The cirrhosis laboratory parameters results showed AST/ALT ratio (1.97 ± 0.45),gamma-GT ((152.33 ± 23.41) U/L),ALP indicators ((232.46 ±35.16) U/L in AC group patients,which were significantly higher in the VC group(1.00± 0.22,(45.89 ± 11.23) U/L and (102.23 ± 21.78) U/L,P =0.035,0.011,0.007 respectively).Conclusion There are difference in term of characteristic,manifestations and the testing laboratory indicators between alcoholic cirrhosis and viral cirrhosis.
