CAJ | 학술논문

目的探讨Notch1在胃肠道类癌中的表达及其与淋巴结转移和患者预后的关系。方法随机选取东莞市人民医院2005年1月至2007年6月诊治的胃肠道恶性肿瘤75例，其中类癌45例，腺癌30例，免疫组化Envision二步法检查Notch1在肿瘤中的表达，并分析其与类癌患者预后和临床病理参数的关系。结果 Notch1在胃肠道类癌中低表达，阳性率为33.33％，而在腺癌组织中高表达，阳性率（62.22％，28/45），两组比较差异有统计学意义（P＜0.05），Notch1在不同临床分期和分化程度患者中存在差异性表达（ P＜0.05），其阳性率与患者年龄、性别、肿物大小、肿物部位及淋巴结转移等无关（ P＞0.05）。 Kaplan-Meier生存分析显示Notch1表达阳性患者具有更长的生存期（ P＜0.05）。结论 Notch1在胃肠道类癌中低表达，与肿物分化程度、患者临床分期和预后相关，具有一定的临床意义。
목적탐토Notch1재위장도유암중적표체급기여림파결전이화환자예후적관계。방법수궤선취동완시인민의원2005년1월지2007년6월진치적위장도악성종류75례，기중유암45례，선암30례，면역조화Envision이보법검사Notch1재종류중적표체，병분석기여유암환자예후화림상병리삼수적관계。결과 Notch1재위장도유암중저표체，양성솔위33.33％，이재선암조직중고표체，양성솔（62.22％，28/45），량조비교차이유통계학의의（P＜0.05），Notch1재불동림상분기화분화정도환자중존재차이성표체（ P＜0.05），기양성솔여환자년령、성별、종물대소、종물부위급림파결전이등무관（ P＞0.05）。 Kaplan-Meier생존분석현시Notch1표체양성환자구유경장적생존기（ P＜0.05）。결론 Notch1재위장도유암중저표체，여종물분화정도、환자림상분기화예후상관，구유일정적림상의의。
Objective To study the expression of Notch 1 in gastrointesinal carcinoid ( GC ) and its relationship with prognosis and lymphatic metastasis .Methods Envision immunohistochemistry was used to detect the expression of Notch1 antibody in 45 cases of GC and 30 cases of gastric adenocarcinoma ( GA) patients selected from our hospital .The association between Notch 1 expression with clinicopathological features in GC was analyzed , and prognosis as well .Results The rate of Notch1 expression was 33.33%in GC,and 62.22% in GA by contrast (P<0.05).The expression of Notch1 protein was associated with clinical stage and degrees of differentiation , showing statistically significant(P<0.05),but it was insignificantly related to age,sex,tumor size,tumor site and lymph node metastasis ( P>0.05 ) .Kaplan-Meier analysis showed that patients with positive Notch 1 expresion have better prognosis ( P<0.05 ) .Conclusions The lower exression of Notch 1 in GC was associated with the clinical stage,prognosis and differentiation .It was useful in the clinical diagnosis .