CAJ | 학술논문

目的探讨五羟色胺转运体启动子区（5-HTTLPR）基因多态性与强迫症患者认知功能、强迫症状之间是否存在关联性。方法采用聚合酶链式反应（ PCR）及扩增片段长度多态性技术检测104例强迫症患者的5-HTTLPR基因的多态性；采用威斯康星卡片分类测试（ WCST ）、连线试验A和B测评所有患者的执行功能、注意；耶鲁-布朗强迫量表（ YBOCS）评估患者的强迫症状。结果不同基因型（ S/S，S/L，L/L）组间强迫症患者的WCST测试、连线测试无显著性差异（ P＞0.05）；并且三个基因型组间强迫症状总分、强迫思维和行为的差异也无统计学意义（ P＞0.05）。结论本研究的结果不支持5-HTTLPR基因多态性作为强迫症临床症状或认知功能损害的候选基因。
목적탐토오간색알전운체계동자구（5-HTTLPR）기인다태성여강박증환자인지공능、강박증상지간시부존재관련성。방법채용취합매련식반응（ PCR）급확증편단장도다태성기술검측104례강박증환자적5-HTTLPR기인적다태성；채용위사강성잡편분류측시（ WCST ）、련선시험A화B측평소유환자적집행공능、주의；야로-포랑강박량표（ YBOCS）평고환자적강박증상。결과불동기인형（ S/S，S/L，L/L）조간강박증환자적WCST측시、련선측시무현저성차이（ P＞0.05）；병차삼개기인형조간강박증상총분、강박사유화행위적차이야무통계학의의（ P＞0.05）。결론본연구적결과불지지5-HTTLPR기인다태성작위강박증림상증상혹인지공능손해적후선기인。
Objective To explore the association between the polymorphism of serotonin transporter promoter region ( 5-HTTLPR ) gene and cognitive function , OCD symptoms in obsessive-compulsive disorder;Methods The polymerase chain reaction ( PCR )-amplified fragment length polymorphism technique was used to exam 5-HTTLPR gene polymorphism in 104 OCD patients;Wisconsin card sorting test (WCST),Trail making test A and B (TMT A and B) were used to test executive function ,attention;Yale-Brown obsessive compulsive scale was employed to evaluate OCD symptoms .Results In this study,No significant difference of WSCT ,TMT A and B ( P>0.05) was found among S/S,S/L,L/L genotypic groups.There was no statistical difference (P >0.05) of OCD symptoms in the three groups either .Conclusion In according to the results of present study ,there is no evidence shows that the polymorphism of 5-HTTLPR gene is related to OCD symptoms or cognitive function .