CAJ | 학술논문

目的探讨早发冠心病（PCAD）患者血清氧化低密度脂蛋白(ox-LDL)及传统心血管危险因子的特征。方法连续选取经冠状动脉造影术确诊的冠心病（CAD）患者66例选入PCAD组，冠脉血管正常的患者56例作为对照组。比较2组患者血清ox-LDL、高密度脂蛋白胆固醇（HDL-C）、三酰甘油（TG）、血肌酐（SCr）、尿酸（UA）等生化指标水平及性别、冠心病家族史、体质指数、高血压史、糖尿病史、吸烟史等的差异。结果（1）PCAD组血清ox-LDL、TG、SCr、UA、空腹血糖（FBG）水平及男性比例高于对照组(P＜0.05)，HDL-C水平低于对照组（P＜0.05），其他指标2组间差异无统计学意义。（2）ox-LDL水平与UA、SCr水平呈正相关，rs分别为0.243（P=0.006）、0.186（P=0.034）。（3）Logis-tic回归分析显示：ox-LDL、HDL-C和SCr是PCAD的影响因素，OR值分别为1.155、0.143、1.052。结论 ox-LDL、HDL-C和SCr异常是PCAD的独立预测因素。
목적탐토조발관심병（PCAD）환자혈청양화저밀도지단백(ox-LDL)급전통심혈관위험인자적특정。방법련속선취경관상동맥조영술학진적관심병（CAD）환자66례선입PCAD조，관맥혈관정상적환자56례작위대조조。비교2조환자혈청ox-LDL、고밀도지단백담고순（HDL-C）、삼선감유（TG）、혈기항（SCr）、뇨산（UA）등생화지표수평급성별、관심병가족사、체질지수、고혈압사、당뇨병사、흡연사등적차이。결과（1）PCAD조혈청ox-LDL、TG、SCr、UA、공복혈당（FBG）수평급남성비례고우대조조(P＜0.05)，HDL-C수평저우대조조（P＜0.05），기타지표2조간차이무통계학의의。（2）ox-LDL수평여UA、SCr수평정정상관，rs분별위0.243（P=0.006）、0.186（P=0.034）。（3）Logis-tic회귀분석현시：ox-LDL、HDL-C화SCr시PCAD적영향인소，OR치분별위1.155、0.143、1.052。결론 ox-LDL、HDL-C화SCr이상시PCAD적독립예측인소。
Objective To investigate the characteristics of serum oxidized low density lipoprotein (ox-LDL) and traditional cardiovascular risk factors of premature coronary artery disease (PCAD). Methods Sixty-six patients with coro-nary atrery disease (CAD) confirmed by angiography were selected to be PCAD group, and 56 patients with normal coronary artery confirmed by angiography were included in control group. The serum levels of ox-LDL, high density lipoprotein choles-terol (HDL-C), triglyceride (TG), creatinine (SCr), uric acid (UA), other serum biochemical indicators and differences of the proportions of male, hypertension, diabetes, smoking history and family history of CAD were compared between two groups. Results (1)There were higher serum values of ox-LDL, TG, SCr, UA, fasting blood glucose (FBG) and proportion of male pa-tients in PCAD group than those of control group (P<0.05), but there was a lower plasma level of HDL-C in PCAD group than that of control group (P<0.05). There were significant differences in other indicators between two groups. (2) There were positive correlations between UA, SCr and ox-LDL ( rs were 0.243 and 0.186 respectively, P were 0.006 and 0.034 respective-ly). (3)The logistic regression analysis showed that ox-LDL, HDL-C and SCr were influential factors to PCAD(OR were 1.155, 0.143 and 1.052 respectively). Conclusion Elevations of ox-LDL, HDL-C and SCr are independent predictors of PCAD.