天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2013年
7期
654-657
,共4页
子宫内膜异位症%趋化因子类%趋化因子CCL5%血清%炎症%免疫%痛经%RANTES
子宮內膜異位癥%趨化因子類%趨化因子CCL5%血清%炎癥%免疫%痛經%RANTES
자궁내막이위증%추화인자류%추화인자CCL5%혈청%염증%면역%통경%RANTES
endometriosis%chemotactic factors%chemokine CCL5%serum%inflammation%immunity%dysmenorrhea%RANTES
目的探讨RANTES在子宫内膜异位症（EM）发生发展中的作用及临床意义。方法采用ELISA方法检测50例EM患者（EM组）、32例卵巢良性肿瘤患者（疾病对照组）以及30例正常妇女（正常对照组）血清中RANTES水平，检测EM组与疾病对照组患者腹腔液中RANTES水平，结合EM患者临床分期等资料进行比较分析。结果EM组患者血清中RANTES水平（108.73±60.69）ng/L明显高于疾病对照组（31.26±20.33）ng/L及正常对照组（29.77±11.58）ng/L（均P<0.05）。EM组腹腔液中RANTES水平（726.31±259.83）ng/L明显高于疾病对照组（116.19±81.64）ng/L （P<0.05）。EM患者血清以及腹腔液中RANTES水平与r-AFS分期均呈正相关(rs分别为0.501和0.562，均P<0.01)；腹腔液中RANTES水平与痛经评分呈正相关（rs=0.527，P<0.01）；血清中RANTES水平与腹腔液中RANTES水平呈正相关（rs=0.363，P=0.01）；血清及腹腔液中RANTES水平分别与病变组织炎症反应程度呈正相关（rs分别为0.326和0.391，P<0.05或P<0.01）。结论 RANTES在EM发生发展中起重要作用，ELISA方法检测EM患者血清中RAN-TES水平可以作为EM诊断的辅助指标。
目的探討RANTES在子宮內膜異位癥（EM）髮生髮展中的作用及臨床意義。方法採用ELISA方法檢測50例EM患者（EM組）、32例卵巢良性腫瘤患者（疾病對照組）以及30例正常婦女（正常對照組）血清中RANTES水平，檢測EM組與疾病對照組患者腹腔液中RANTES水平，結閤EM患者臨床分期等資料進行比較分析。結果EM組患者血清中RANTES水平（108.73±60.69）ng/L明顯高于疾病對照組（31.26±20.33）ng/L及正常對照組（29.77±11.58）ng/L（均P<0.05）。EM組腹腔液中RANTES水平（726.31±259.83）ng/L明顯高于疾病對照組（116.19±81.64）ng/L （P<0.05）。EM患者血清以及腹腔液中RANTES水平與r-AFS分期均呈正相關(rs分彆為0.501和0.562，均P<0.01)；腹腔液中RANTES水平與痛經評分呈正相關（rs=0.527，P<0.01）；血清中RANTES水平與腹腔液中RANTES水平呈正相關（rs=0.363，P=0.01）；血清及腹腔液中RANTES水平分彆與病變組織炎癥反應程度呈正相關（rs分彆為0.326和0.391，P<0.05或P<0.01）。結論 RANTES在EM髮生髮展中起重要作用，ELISA方法檢測EM患者血清中RAN-TES水平可以作為EM診斷的輔助指標。
목적탐토RANTES재자궁내막이위증（EM）발생발전중적작용급림상의의。방법채용ELISA방법검측50례EM환자（EM조）、32례란소량성종류환자（질병대조조）이급30례정상부녀（정상대조조）혈청중RANTES수평，검측EM조여질병대조조환자복강액중RANTES수평，결합EM환자림상분기등자료진행비교분석。결과EM조환자혈청중RANTES수평（108.73±60.69）ng/L명현고우질병대조조（31.26±20.33）ng/L급정상대조조（29.77±11.58）ng/L（균P<0.05）。EM조복강액중RANTES수평（726.31±259.83）ng/L명현고우질병대조조（116.19±81.64）ng/L （P<0.05）。EM환자혈청이급복강액중RANTES수평여r-AFS분기균정정상관(rs분별위0.501화0.562，균P<0.01)；복강액중RANTES수평여통경평분정정상관（rs=0.527，P<0.01）；혈청중RANTES수평여복강액중RANTES수평정정상관（rs=0.363，P=0.01）；혈청급복강액중RANTES수평분별여병변조직염증반응정도정정상관（rs분별위0.326화0.391，P<0.05혹P<0.01）。결론 RANTES재EM발생발전중기중요작용，ELISA방법검측EM환자혈청중RAN-TES수평가이작위EM진단적보조지표。
Objective To investigate the role and clinical significance of RANTES in endometriosis (EM). Methods The serum level of RANTES was examined by ELISA in 50 patients with endometriosis (EM group), 32 patients with benign ovarian neoplasms (disease control group) and 30 normal control women (normal control group). The level of RANTES in peritoneal fluid was examined in EM group and disease control group. Results The serum level of RANTES was significantly higher in EM group (108.73±60.69) ng/L than that of disease control group (31.26±20.33) ng/L and normal control group (29.77 ± 11.58) ng/L (P<0.05). The level of RANTES in peritoneal fluid was significantly higher in EM group (726.31 ± 259.83) ng/L than that of disease control group (116.19 ± 81.64) ng/L (P<0.05). The levels of RANTES in serum and peritoneal fluid in EM group were positively correlated with clinical stage respectively (rs=0.501 and 0.562,P<0.01). The level of RANTES in peritoneal fluid in EM group was positively correlated with dysmenorrhea score (rs=0.527,P<0.01). The serum level of RANTES was positively correlated with the level of RANTES in peritoneal fluid in EM group (rs=0.363, P<0.05). The levels of RANTES in serum and peritoneal fluid were positively correlated with inflammatory response degree in endometriotic tissues in EM group (rs=0.326 and 0.391,P<0.05 or P<0.01).Conclusion Detection of the serum level of RANTES by ELISA may be one of parameters for diagnosis of endometriosis.
