CAJ | 학술논문

目的：研究Mina基因rs4857304（ G/T）位点和IL-4基因位点rs2243248（ T/G）、rs2070874（ T/C）单核苷酸多态性与我国汉族儿童过敏性哮喘发病的相关性，并进一步分析3个位点之间的交互作用。方法：采用病例对照研究方法，分析不同等位基因频率和基因型在哮喘患者和对照组患者中的分布差异，及其交互作用。结果：将两组患者Mina的rs4857304位点进行比较，哮喘组患者的位点等位基因T频率高于对照组，差异有统计学意义（ P＝0．001，OR＝1．773，95％CI＝1．256～2．503）；而两组的基因型分布则无显著差异（P＞0．05）；交互作用的MDR分析显示，Mina基因位点rs4857304和IL-4基因位点rs2243248构成的2个位点最佳模型；Mina位点rs4857304和IL-4基因位点rs2070874和rs2243248构成的3个位点最佳模型。两组比较差异有统计学意义（P＜0．05）。结论：过敏性哮喘与Mina位点rs4857304具有相关性，同时Mina rs4857304与IL-4位点rs2243248、rs2070804具有显著的交互作用。
목적：연구Mina기인rs4857304（ G/T）위점화IL-4기인위점rs2243248（ T/G）、rs2070874（ T/C）단핵감산다태성여아국한족인동과민성효천발병적상관성，병진일보분석3개위점지간적교호작용。방법：채용병례대조연구방법，분석불동등위기인빈솔화기인형재효천환자화대조조환자중적분포차이，급기교호작용。결과：장량조환자Mina적rs4857304위점진행비교，효천조환자적위점등위기인T빈솔고우대조조，차이유통계학의의（ P＝0．001，OR＝1．773，95％CI＝1．256～2．503）；이량조적기인형분포칙무현저차이（P＞0．05）；교호작용적MDR분석현시，Mina기인위점rs4857304화IL-4기인위점rs2243248구성적2개위점최가모형；Mina위점rs4857304화IL-4기인위점rs2070874화rs2243248구성적3개위점최가모형。량조비교차이유통계학의의（P＜0．05）。결론：과민성효천여Mina위점rs4857304구유상관성，동시Mina rs4857304여IL-4위점rs2243248、rs2070804구유현저적교호작용。
Objective:To study the relevance of Mina rs4857304 (G/T) gene locus, IL-4 gene locus rs2243248 (T/G), rs2070874 ( T/C ) single nucleotide polymorphism and allergic asthma pathogenesis of Chinese children , and further analysis of the in-teraction among three loci.Methods:Based on the case-control study, we have analyzed the different distributions , frequencies, inter-action of alleles and genotypes between asthma patients and patients in control group .Results: The Mina rs4857304 sites of patients were compared, and there was statistically significant difference between two groups ( P=0.001, OR =1.773,95%CI =1.256 -2.503);the rs4857304T allelic frequency of patients with asthma was higher than that of the patients in control group , but there was no statistically significant difference about the distribution of different locus genotypes of patients between two groups (P>0.05);MDR interaction analysis have showed that Mina gene loci , rs4857304 and IL-4loci rs2243248, consisting of 2 sites optimal model;Mina loci rs4857304, IL-4loci rs2070874 and rs2243248 that consisting of 3 sites optimal model.There was statistically significant difference be-tween two groups(P<0.05).Conclusion:Allergic asthma would be associated with Mina loci rs4857304, while there might be sig-nificant interactive effects among Mina rs4857304, IL-4loci rs2243248 and rs2070804.