中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
8期
3389-3393
,共5页
孟翠菊%张广美%付亮亮%郭秋艳%刘骥
孟翠菊%張廣美%付亮亮%郭鞦豔%劉驥
맹취국%장엄미%부량량%곽추염%류기
卵巢肿瘤%肿瘤转移%预后%免疫组织化学%p53 R2
卵巢腫瘤%腫瘤轉移%預後%免疫組織化學%p53 R2
란소종류%종류전이%예후%면역조직화학%p53 R2
Ovarian neoplasms%Neoplasm metastasis%Prognosis%Immunohistochemistry%p53 R2
目的探讨核糖核苷酸还原酶小亚基（ p53 R2）在卵巢上皮性肿瘤中的表达及其临床病理意义。方法应用免疫组织化学方法检测66例上皮性卵巢癌组织，20例上皮性卵巢交界性肿瘤组织、36例上皮性卵巢良性肿瘤组织、20例卵巢组织中p53 R2蛋白的表达情况，并分析其与卵巢癌临床病理特征的关系。结果免疫组化检测结果显示，上皮性卵巢癌组织中p53 R2蛋白表达阳性率为72.7％（48/66），交界性上皮性卵巢肿瘤中为50％（10/20），卵巢上皮性良性肿瘤组织中为46％（15/36），正常卵巢组织为5％（1/20）；低分化肿瘤组织中p53 R2蛋白表达阳性率显著高于中、高分化者（ P＜0.05）；并发肝转移的癌组织中p53 R2表达高于无肝转移组（ P＜0.01）；p53 R2蛋白表达与有无淋巴结转移无关（ P＞0.05）；p53 R2蛋白高表达者，术后生存时间短（ P＜0.05）。结论上皮性卵巢癌中p53 R2蛋白表达阳性率明显增高，并与卵巢癌病情进展有关，可望作为卵巢癌患者独立的预后指标。
目的探討覈糖覈苷痠還原酶小亞基（ p53 R2）在卵巢上皮性腫瘤中的錶達及其臨床病理意義。方法應用免疫組織化學方法檢測66例上皮性卵巢癌組織，20例上皮性卵巢交界性腫瘤組織、36例上皮性卵巢良性腫瘤組織、20例卵巢組織中p53 R2蛋白的錶達情況，併分析其與卵巢癌臨床病理特徵的關繫。結果免疫組化檢測結果顯示，上皮性卵巢癌組織中p53 R2蛋白錶達暘性率為72.7％（48/66），交界性上皮性卵巢腫瘤中為50％（10/20），卵巢上皮性良性腫瘤組織中為46％（15/36），正常卵巢組織為5％（1/20）；低分化腫瘤組織中p53 R2蛋白錶達暘性率顯著高于中、高分化者（ P＜0.05）；併髮肝轉移的癌組織中p53 R2錶達高于無肝轉移組（ P＜0.01）；p53 R2蛋白錶達與有無淋巴結轉移無關（ P＞0.05）；p53 R2蛋白高錶達者，術後生存時間短（ P＜0.05）。結論上皮性卵巢癌中p53 R2蛋白錶達暘性率明顯增高，併與卵巢癌病情進展有關，可望作為卵巢癌患者獨立的預後指標。
목적탐토핵당핵감산환원매소아기（ p53 R2）재란소상피성종류중적표체급기림상병리의의。방법응용면역조직화학방법검측66례상피성란소암조직，20례상피성란소교계성종류조직、36례상피성란소량성종류조직、20례란소조직중p53 R2단백적표체정황，병분석기여란소암림상병리특정적관계。결과면역조화검측결과현시，상피성란소암조직중p53 R2단백표체양성솔위72.7％（48/66），교계성상피성란소종류중위50％（10/20），란소상피성량성종류조직중위46％（15/36），정상란소조직위5％（1/20）；저분화종류조직중p53 R2단백표체양성솔현저고우중、고분화자（ P＜0.05）；병발간전이적암조직중p53 R2표체고우무간전이조（ P＜0.01）；p53 R2단백표체여유무림파결전이무관（ P＞0.05）；p53 R2단백고표체자，술후생존시간단（ P＜0.05）。결론상피성란소암중p53 R2단백표체양성솔명현증고，병여란소암병정진전유관，가망작위란소암환자독립적예후지표。
Objective To investigate the expression of p 53R2 in epithelial ovarian neoplasm and its clinicopathological significance .Methods Immunohistochemistry were performed to examine the protein expression in 66 epithelial ovarian carcinomas ,20 borderline epithelial tumors ,36 benign cystadenomas epithelial ovarian ,and 20 normal ovaries using a standard streptavidin-biotin-peroxidase complex method .The correlation between p53R2 expression and clinico-pathological features was analyzed .Results In immunohistochemistry study , the positive expression rate of p53R2 protein in epithelial ovarian cancer tissue was 72.7%(48/66),50%(10/20)in borderline epithelial ovarian tumors,46%(15/36)in epithelial ovarian benign tumors ,5%(1/20)in normal ovarian tissue;The positive rate of p53R2 was significantly higher in the poorly-differentiated ovarian cancer than in the moderately-and well-differentiated ovarian cancer ( P <0.05 ).The positive rate of p53R2 was higher than in concurrent liver metastases of cancer tissue than those without liver metastasis group (P<0.01).The p53R2 protein expression was not statistically significant with lymph node metastasis (P >0.05).The higher expression of p53R2 protein,the shorter postoperative survival time (P <0.05).Conclusions The positive expression rate of p53R2 protein are significantly higher in epithelial ovarian cancer tissue , and was associated closely with the progression of ovarian carcinomas ,and is expected to become an independent parameter of patients with ovarian cancer .
