中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2013年
8期
56-58
,共3页
王智%王爽%许贵军%高菲
王智%王爽%許貴軍%高菲
왕지%왕상%허귀군%고비
枣地安神丸%质量标准%薄层色谱法%五味子醇甲%五味子甲素%五味子乙素%高效液相色谱法
棘地安神汍%質量標準%薄層色譜法%五味子醇甲%五味子甲素%五味子乙素%高效液相色譜法
조지안신환%질량표준%박층색보법%오미자순갑%오미자갑소%오미자을소%고효액상색보법
Zaodi Anshen Pills%quality standard%TLC%schisandrin%deoxyschizandrin%schisandrin B%HPLC
目的建立枣地安神丸的质量标准。方法采用薄层色谱法对制剂中酸枣仁、制何首乌进行定性鉴别。采用高效液相色谱法对五味子醇甲、五味子甲素和五味子乙素进行含量测定,用Eclipse XDB-C18色谱柱(250 mm×4.6 mm,5μm),流动相为甲醇-水梯度洗脱,流速1.0 mL/min,柱温40℃,检测波长254 nm。结果酸枣仁、制何首乌薄层色谱斑点清晰,分离效果较好,且阴性无干扰。五味子醇甲、五味子甲素和五味子乙素分别在338~1690 ng(r2=0.9991)、128~640 ng(r2=0.9993)、236~1180 ng(r2=0.9994)范围内呈良好的线性关系,平均加样回收率分别为99.2%、99.0%、98.9%。结论本方法准确可靠、专属性强、重复性好,可作为枣地安神丸的质量控制标准。
目的建立棘地安神汍的質量標準。方法採用薄層色譜法對製劑中痠棘仁、製何首烏進行定性鑒彆。採用高效液相色譜法對五味子醇甲、五味子甲素和五味子乙素進行含量測定,用Eclipse XDB-C18色譜柱(250 mm×4.6 mm,5μm),流動相為甲醇-水梯度洗脫,流速1.0 mL/min,柱溫40℃,檢測波長254 nm。結果痠棘仁、製何首烏薄層色譜斑點清晰,分離效果較好,且陰性無榦擾。五味子醇甲、五味子甲素和五味子乙素分彆在338~1690 ng(r2=0.9991)、128~640 ng(r2=0.9993)、236~1180 ng(r2=0.9994)範圍內呈良好的線性關繫,平均加樣迴收率分彆為99.2%、99.0%、98.9%。結論本方法準確可靠、專屬性彊、重複性好,可作為棘地安神汍的質量控製標準。
목적건립조지안신환적질량표준。방법채용박층색보법대제제중산조인、제하수오진행정성감별。채용고효액상색보법대오미자순갑、오미자갑소화오미자을소진행함량측정,용Eclipse XDB-C18색보주(250 mm×4.6 mm,5μm),류동상위갑순-수제도세탈,류속1.0 mL/min,주온40℃,검측파장254 nm。결과산조인、제하수오박층색보반점청석,분리효과교호,차음성무간우。오미자순갑、오미자갑소화오미자을소분별재338~1690 ng(r2=0.9991)、128~640 ng(r2=0.9993)、236~1180 ng(r2=0.9994)범위내정량호적선성관계,평균가양회수솔분별위99.2%、99.0%、98.9%。결론본방법준학가고、전속성강、중복성호,가작위조지안신환적질량공제표준。
Objecfive To establish the quality standard of Zaodi Anshen Pills. Methods TLC method was used to identify Spinosae and Radix polygoni Multiflori. HPLC method was used to determine the schisandrin, deoxyschizandrin and schisandrin B. Eclipse XDB-C18 column (250 mm×4.6 mm, 5 μm) was adopted by gradient elution using MeOH-water solution as the mobile phase. The detection wavelength was at 254 nm, column temperature was at 40 ℃ and the flow rate was 1.0 mL/min. Results The TLC spots were clear without interference of the negative control. The linear ranges of schisandrin, deoxyschizandrin and schisandrin B were within 338-1690 ng (r 2=0.999 1), 128-640 ng (r 2=0.999 3) and 236-1180 ng (r 2=0.999 4), and the average recoveries were 99.2%, 99.0% and 98.9% respectively. Conclusion This method is accurate, reliable, specific and reproducible, and can be used for quality control of Zaodi Anshen Pills.