CAJ | 학술논문

目的：评价托烷司琼用于预防急诊剖宫产术围术期恶心呕吐的效果。方法：选择急诊非禁食的剖宫产手术患者200例,随机分为2组,A组(n=100)于麻醉前和手术结束时分别静脉注射托烷司琼2mg；B组(n=100)麻醉前和手术结束时均未使用托烷司琼。分别观察并记录给药前1分钟(T0)、手术开始前1分钟(T1)、手术开始后10分钟(T2)、手术结束时(T3)平均动脉压(MAP)的变化,新生儿断脐后1分钟给予Apgar评分,并观察术中恶心呕吐(IONV)和24h术后恶心呕吐(PONV)的发生情况,药物相关的不良反应。结果：A组患者IONV发生率为12％,PONV发生率为9％；B组患者IONV发生率为38％,PONV发生率为31％。A组与B组间IONV、PONV均有显著差异(P<0.01)。两组间MAP、Apgar评分无差异(P>0.05)。偶见头晕头疼,未发现药物相关的过敏反应和锥体外系症状。结论：麻醉前和术毕时分别静脉注射托烷司琼2mg能有效预防和减少急诊剖宫产围术期恶心呕吐的发生,对MAP和新生儿Apgar评分无明显影响。
목적：평개탁완사경용우예방급진부궁산술위술기악심구토적효과。방법：선택급진비금식적부궁산수술환자200례,수궤분위2조,A조(n=100)우마취전화수술결속시분별정맥주사탁완사경2mg；B조(n=100)마취전화수술결속시균미사용탁완사경。분별관찰병기록급약전1분종(T0)、수술개시전1분종(T1)、수술개시후10분종(T2)、수술결속시(T3)평균동맥압(MAP)적변화,신생인단제후1분종급여Apgar평분,병관찰술중악심구토(IONV)화24h술후악심구토(PONV)적발생정황,약물상관적불량반응。결과：A조환자IONV발생솔위12％,PONV발생솔위9％；B조환자IONV발생솔위38％,PONV발생솔위31％。A조여B조간IONV、PONV균유현저차이(P<0.01)。량조간MAP、Apgar평분무차이(P>0.05)。우견두훈두동,미발현약물상관적과민반응화추체외계증상。결론：마취전화술필시분별정맥주사탁완사경2mg능유효예방화감소급진부궁산위술기악심구토적발생,대MAP화신생인Apgar평분무명현영향。
Objective:To evaluate the efficacy of the prevention of perioperative nausea and vomiting with Tropisetron in patients undergoing emergency cesarean section. Methods:200 patients, gastric satiety, undergoing emergency cesarean section, were randomly divided into two groups:Group A( n=100) and Group B (n=100). Group A, Tropisetron 2mg iv each time, at the time of before anesthesia, completion of operation;Group B, unused Tropisetron at the time of before anesthesia, completion of operation. Record the value of MAP, at time of 1min before drug administration (T0), 1min before the beginning of operation (T1), 10min after the beginning of operation, end of surgery (T3), the neonatal Apgar score at the time of 1min after Cutting umbilical cord. The episodes of intraoperative nausea and vomiting (IONV) and postoperative nausea and vomiting (PONV) within 24h postoperatively, the drug related adverse reactions, were studied respectively. Results: Group A, incidence of IONV and PONV were 12% and 9% respectively. Group B, incidence of IONV and PONV were 38%and 31%respectively. Significant differences were observed in incidence of IONV and PONV between the two groups(P<0.01). The value of MAP and Apgar score were no difference between Group A and Group B(P>0.05).No the drug related allergic reaction and extrapyramidal symptoms were observed except Occasional Headache and dizziness. Conclusion: In patients undergoing emergency cesarean section, Tropisetron of 2mg each time at the time of before anesthesia, completion of operation, had the better efficacy on preventing IONV and PONV. Tropisetron had no significant effect on MAP and neonatal score.