CAJ | 학술논문

目的：探讨BIS监测下靶控输注不同浓度异丙酚对七氟烷MACBAR50的影响。方法：择期在静吸复合全身麻醉下行腹部手术患者50例,采用随机数字法,将患者分为5组(n=10),(即P0,P1,P2,P3和P4组),异丙酚血浆靶浓度分别为(0,1,1.5,2.0,2.5)μg/ml组。采用序贯法测定七氟烷使50%患者切皮时不发生交感反应的最低肺泡有效浓度(MACBAR50)。同时监测BIS值。结果：P0组七氟烷MACBAR50为(2.40±0.20)%,P1组为(2.14±0.24)%,P2组为(1.90±0.13)%,P3组为(1.68±0.16)%,P4组为(1.50±0.16)%。5组间比较差异有统计学意义(P<0.05)。靶控输注浓度(1,1.5,2.0,2.5)μg/ml的异丙酚可分别降低七氟烷MACBAR5012.5%,20.8%,30.0%,37.5%。结论：靶控输注异丙酚可以降低七氟烷的MACBAR50,不同靶浓度异丙酚对七氟烷MACBAR50的影响不同,随着异丙酚靶浓度增大,七氟烷MACBAR50逐渐降低,BIS值逐渐降低。
목적：탐토BIS감측하파공수주불동농도이병분대칠불완MACBAR50적영향。방법：택기재정흡복합전신마취하행복부수술환자50례,채용수궤수자법,장환자분위5조(n=10),(즉P0,P1,P2,P3화P4조),이병분혈장파농도분별위(0,1,1.5,2.0,2.5)μg/ml조。채용서관법측정칠불완사50%환자절피시불발생교감반응적최저폐포유효농도(MACBAR50)。동시감측BIS치。결과：P0조칠불완MACBAR50위(2.40±0.20)%,P1조위(2.14±0.24)%,P2조위(1.90±0.13)%,P3조위(1.68±0.16)%,P4조위(1.50±0.16)%。5조간비교차이유통계학의의(P<0.05)。파공수주농도(1,1.5,2.0,2.5)μg/ml적이병분가분별강저칠불완MACBAR5012.5%,20.8%,30.0%,37.5%。결론：파공수주이병분가이강저칠불완적MACBAR50,불동파농도이병분대칠불완MACBAR50적영향불동,수착이병분파농도증대,칠불완MACBAR50축점강저,BIS치축점강저。
Objective:To investigate the BIS monitoring under the effect of target controlled infusion of propofol of different concentrations of sevoflurane MACBAR50.Methods:The patients in intravenous anesthesia for elective abdominal operation in 50 cases,randomly, the patients were divided into 5 groups (n=10),(P0,P1,P2,P3 and P4 group),target plasma concentration of propofol respectively (0,1,1.5,2.0,2.5)μg/ml group.Determination of MACBAR50 of sevoflurane using sequential method.At the same time monitoring BIS value.Results:In P0 group,MACBAR50 of sevoflurane (2.40±0.20)% for P1 group,(2.14±0.24)%,group P2 was (1.90±0.13)%,group P3 was (1.68±0.16)%,group P4 was (1.50±0.16)%.There was statistically significant difference between 5 groups (P<0.05).Target controlled infusion concentration of (1,1.5,2.0,2.5) μg/ml propofol can decrease the MACBAR50 of sevoflurane respectively 12.5%,20.8%,30%,37.5%.Conclusion:Target controlled infusion of propofol can reduce the MACBAR50 of sevoflurane,effects of different target plasma concentrations of propofol on MACBAR50 of sevoflurane is different,with the increase of target concentration of propofol,sevoflurane decreased MACBAR50,BIS value is gradually reduced.