CAJ | 학술논문

目的探讨高血压合并颈动脉硬化中医证型与脂联素水平及颈动脉斑块的关系，为临床诊疗提供客观依据。方法将100例高血压合并颈动脉硬化患者辨证分为痰证组、瘀证组、痰瘀互结证组，并与健康对照组30例进行比较。采用GE LOGIQ500型多功能彩超诊断仪检测颈动脉斑块形成情况，采用酶联免疫吸附法(ELISA)测定血清脂联素(APN)水平。结果痰瘀互结证组APN水平显著低于其他组，各组APN水平差异有统计学意义；痰瘀互结证组形成斑块较多见。颈动脉内膜-中层厚度(IMT)与APN呈负相关。结论高血压合并颈动脉硬化患者中医证型与APN及颈动脉斑块有一定相关性，根据中医证型可初步判断其APN的异常变化及斑块形成情况。
목적탐토고혈압합병경동맥경화중의증형여지련소수평급경동맥반괴적관계，위림상진료제공객관의거。방법장100례고혈압합병경동맥경화환자변증분위담증조、어증조、담어호결증조，병여건강대조조30례진행비교。채용GE LOGIQ500형다공능채초진단의검측경동맥반괴형성정황，채용매련면역흡부법(ELISA)측정혈청지련소(APN)수평。결과담어호결증조APN수평현저저우기타조，각조APN수평차이유통계학의의；담어호결증조형성반괴교다견。경동맥내막-중층후도(IMT)여APN정부상관。결론고혈압합병경동맥경화환자중의증형여APN급경동맥반괴유일정상관성，근거중의증형가초보판단기APN적이상변화급반괴형성정황。
Objectives To study the relationship between TCM syndromes and adiponectin (APN) level, carotid atherosclerosis plaque of hypertension complicated with carotid atherosclerosis, and provide evidence for clinical diagnosis and treatment. Methods One hundred patients of hypertension complicated with carotid atherosclerosis were divided into phlegm syndrome group, stasis syndrome group, and intermingled phlegm and blood stasis syndrome group, and compared with 30 healthy people as control. Carotid atherosclerosis plaque was detected with GE LOGIQ500 color ultrasound system. ELISA was used to determine the serum APN. Results APN of the intermingled phlegm and blood stasis syndrome group was obviously lower than other groups, and there were obvious differences among them. There were more plaques in the intermingled phlegm and blood stasis syndrome group. A negative correlationship was showed between carotid artery intima media thickness (IMT) and APN of hypertension complicated with carotid atherosclerosis. Conclusion There is correlation between TCM syndrome and APN level, carotid atherosclerosis plaque of hypertension complicated with carotid atherosclerosis. The anomalous change of APN and plaque formation of the patients can be preliminarily estimated with the syndrome of TCM.