CAJ | 학술논문

目的观察稳消方干预颈动脉粥样硬化(CAS)斑块形成患者颈动脉斑块变化情况,同时评估用药安全性。方法将60例CAS斑块形成患者随机分为干预组33例及对照组27例,对照组予常规治疗,干预组在常规治疗基础上加用稳消方,并进一步分为干预半年组与对照半年组、干预1年组与对照1年组进行比较,采用颈动脉彩色多普勒超声评估斑块状况,同时测定肝、肾功能指标。结果与对照组治疗后比较,干预半年组及1年组平均斑块数量、斑块最大厚度、Crouse积分比较差异有统计学意义(P＜0.05,P＜0.01),而斑块的稳定性干预1年组优于半年组；与本组治疗前比较,对照组斑块数量增多、增大,Crouse积分增加(P＜0.05,P＜0.01)。干预组及对照组双侧颈总动脉内径、内膜-中层厚度及肝、肾功能治疗前后比较差异均无统计学意义(P＞0.05)。结论稳消方治疗CAS斑块形成疗效确切、安全性良好,且随干预时间延长,稳定斑块趋势更为明显。
목적관찰은소방간예경동맥죽양경화(CAS)반괴형성환자경동맥반괴변화정황,동시평고용약안전성。방법장60례CAS반괴형성환자수궤분위간예조33례급대조조27례,대조조여상규치료,간예조재상규치료기출상가용은소방,병진일보분위간예반년조여대조반년조、간예1년조여대조1년조진행비교,채용경동맥채색다보륵초성평고반괴상황,동시측정간、신공능지표。결과여대조조치료후비교,간예반년조급1년조평균반괴수량、반괴최대후도、Crouse적분비교차이유통계학의의(P＜0.05,P＜0.01),이반괴적은정성간예1년조우우반년조；여본조치료전비교,대조조반괴수량증다、증대,Crouse적분증가(P＜0.05,P＜0.01)。간예조급대조조쌍측경총동맥내경、내막-중층후도급간、신공능치료전후비교차이균무통계학의의(P＞0.05)。결론은소방치료CAS반괴형성료효학절、안전성량호,차수간예시간연장,은정반괴추세경위명현。
Objective To observe the effect of Wenxiao Decoction in treating the patients with carotid atherosclerostic (CAS) plaque and assess the safety. Methods Sixty patients with CAS plaque were randomly allocated to treatment group (33 cases) and control group (27 cases). The control group was given routine therapy, and the treatment group was given Wenxiao Decoction additionally. And they were further divided into half-year treatment group and half-year control group, 1-year treatment group and 1-year control group. Carotid artery color Doppler ultrasound and hepatorenal function were examined before and after treatment. Results Compared with the control groups after therapy, the average numbers of plaques, maximal plaque thickness, Crouse plaque integral were decreased both in 1-year and half-year treatment groups (P<0.05, P<0.01). The plaque stability of 1-year treatment group was better than that of half-year treatment group. The average numbers of plaques, plaques size and Crouse plaque integral increased in control groups after routine therapy (P<0.05, P<0.01). Bilateral common carotid artery diameter, intima-medial thickness (IMT) and hepatorenal function had no statistical difference between before and after treatment both in treatment and control groups (P>0.05). Conclusion Wenxiao Decoction is effective and safe in treatment of CAS plaque, and plaque stability is more obvious with the extension of treatment time.