CAJ | 학술논문

目的探讨糖尿病肾脏损害的相关因素。方法将符合入选标准的168例2型糖尿病患者根据有无糖尿病肾病分为糖尿病肾病组（DN组，90例）和非糖尿病肾病组（非DN组，78例），DN组再分为DN早期组（62例）和DN 中晚期组（28例），进行糖尿病肾脏损害的相关因素分析。结果 DN组与非DN组间空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白a、载脂蛋白b比较差异无统计学意义（P ＞0．05）；高血压、脂蛋白a和纤维蛋白原差异有统计学意义（P ＜0．05）；内生肌酐清除率和尿微量白蛋白组间差异有统计学意义（P ＜0．01）。3组间比较，DN早期组与非DN组间脂蛋白a差异有统计学意义（P ＜0．01），但尿微量白蛋白（UAE）差异无统计学意义（P ＞0．05）。Logistic回归显示脂蛋白a是糖尿病肾病的危险因素，文化程度是糖尿病肾病的保护因素。结论脂蛋白a与糖尿病肾病损害程度密切相关，随着糖尿病肾病的加重，脂蛋白a进行性升高。脂蛋白a可以作为早期预测指标。
목적탐토당뇨병신장손해적상관인소。방법장부합입선표준적168례2형당뇨병환자근거유무당뇨병신병분위당뇨병신병조（DN조，90례）화비당뇨병신병조（비DN조，78례），DN조재분위DN조기조（62례）화DN 중만기조（28례），진행당뇨병신장손해적상관인소분석。결과 DN조여비DN조간공복혈당、당화혈홍단백、감유삼지、총담고순、고밀도지단백、저밀도지단백、재지단백a、재지단백b비교차이무통계학의의（P ＞0．05）；고혈압、지단백a화섬유단백원차이유통계학의의（P ＜0．05）；내생기항청제솔화뇨미량백단백조간차이유통계학의의（P ＜0．01）。3조간비교，DN조기조여비DN조간지단백a차이유통계학의의（P ＜0．01），단뇨미량백단백（UAE）차이무통계학의의（P ＞0．05）。Logistic회귀현시지단백a시당뇨병신병적위험인소，문화정도시당뇨병신병적보호인소。결론지단백a여당뇨병신병손해정도밀절상관，수착당뇨병신병적가중，지단백a진행성승고。지단백a가이작위조기예측지표。
Objective To analyze the related factors of diabetic nephropathy . Methods According to whether the patients suffered from diabetic nephropathy or not ,we divided the 168 patients into 2 groups (non-diabetic nephropathy group and nephropathy group ) in order to analyze the related factors w hich may low dow n the renal function .Results T he number of non-diabetic nephropathy patient is 78 and the num-ber of the diabetic nephropathy patient is 90 .Between DN group and non-DN group ,fasting plasma glu-cose (FPG) ,Glycohemoglobin A (HbA1C) ,triglyeride (TG) ,total cholesterol (TC) ,high-density lipo-protein HDL-C ,low-density lipoprotein (LDL-C) ,ApoA ,ApoB had no statistical disparity (P >0 .05) . LPa and FIB had statistical disparity between DN group and non-DN group (P<0 .05) .Ccr and UAE had significantly statistical disparity between DN group and non-DN group (P <0 .01) .Comparisons between three groups showed that LPa had significantly statistical disparity between earlier DN jm group and non-DN group (P <0 .01) ,but UAE had no statistical disparity (P>0 .05) .Logistic return showed that LPa was hazards of DN .The protection of oneself depends on his cultural degree .Conclusion LPa takes part in the progress of DN ,and is crossly-related with the extent of damage of DN ,LPa is gradually increasing according to the extent of damage of DN .We could use LPa as early prediction index .