CAJ | 학술논문

目的探讨采用不同药物湿敷预防CHOP方案化疗所致静脉炎的效果。方法选择120例第1次使用CHOP方案化疗的患者，随机分为两组：观察组：化疗前30min给予25％硫酸镁联合2％利多卡因局部湿敷穿刺点上方沿静脉走向5～10cm处，至静推结束约2h；对照组：应用25％硫酸镁湿敷，湿敷时点、时长及部位同观察组。观察两组静脉炎发生率及湿敷预防静脉炎有效率。结果观察组静脉炎发生18例（30．0％），对照组38例（63．3％）；观察组湿敷预防静脉炎有效48例（80．0％），对照组有效31例（51．7％），两组有效率比较差异有统计学意义（P＜0．05）。结论25％硫酸镁联合2％利多卡因局部湿敷能更好地预防CHOP方案化疗引起的静脉炎。
목적탐토채용불동약물습부예방CHOP방안화료소치정맥염적효과。방법선택120례제1차사용CHOP방안화료적환자，수궤분위량조：관찰조：화료전30min급여25％류산미연합2％리다잡인국부습부천자점상방연정맥주향5～10cm처，지정추결속약2h；대조조：응용25％류산미습부，습부시점、시장급부위동관찰조。관찰량조정맥염발생솔급습부예방정맥염유효솔。결과관찰조정맥염발생18례（30．0％），대조조38례（63．3％）；관찰조습부예방정맥염유효48례（80．0％），대조조유효31례（51．7％），량조유효솔비교차이유통계학의의（P＜0．05）。결론25％류산미연합2％리다잡인국부습부능경호지예방CHOP방안화료인기적정맥염。
Objective To investigate the effects of preventing phlebitis caused by CHOP regimen with wet compressing of different drugs .Methods To select 120 patients who accpeted CHOP regimens for the first time and divide them into two groups randomly .Observation group :local wet compressing with 25%magnesium sulfate mixed with 2% lidocaine in the puncture point along the vein to 5 -10 cm ahead of 30 minutes before chemotherapy ,static push for 2 h ;control group :wet compressing with 25% magnesium sulfate ,the time and position of wet compressing were as the same as those of observation group .Compa-ring the incidence of phlebitis between two groups and effects of wet compressing against phlebitis .Result 18 cases (30 .0% ) of phlebitis in observation group and 38 (63 .3% ) in control group ;48 cases (80 .0% ) have been proved to be effective by using the method and 31 (51 .7% ) in control group .The differences between two groups were statistically significant (P <0 .05) .Conclusion Magnesium sulfate mixed with lidocaine can effectively prevent phlebitis caused by CHOP regimen .