CAJ | 학술논문

目的探讨hM L H3基因2531位点多态性及环境因素与新疆哈萨克族食管癌家族式高发率的关系。方法通过检测86例新疆哈萨克族食管癌家族成员及82例对照家族成员外周血hM L H3基因的多态性，并通过对环境危险因素进行现场问卷调查，研究hM L H3基因多态性和环境因素在新疆哈萨克族食管癌家族食管癌发病中所起的作用。结果新疆哈萨克族食管癌家族与对照家族hM L H3基因2531位点不同基因型的分布频率差异有统计意义（P ＝0．018）；食管癌患者与非食管癌患者hMLH3基因2531位点不同基因型的分布频率差异无统计意义（P ＝0．653）；吸烟、饮酒、辛辣食物、腌熏食物、饮水情况、摄入新鲜蔬菜水果等环境因素均未显示与hM-L H3基因2531位点基因多态性有相关性。结论 hM L H3基因2531位点多态性与新疆哈萨克族食管癌家族的聚集性相关，未发现hM L H3基因2531位点多态性与新疆哈萨克族食管癌的发病及环境因素有关。
목적탐토hM L H3기인2531위점다태성급배경인소여신강합살극족식관암가족식고발솔적관계。방법통과검측86례신강합살극족식관암가족성원급82례대조가족성원외주혈hM L H3기인적다태성，병통과대배경위험인소진행현장문권조사，연구hM L H3기인다태성화배경인소재신강합살극족식관암가족식관암발병중소기적작용。결과신강합살극족식관암가족여대조가족hM L H3기인2531위점불동기인형적분포빈솔차이유통계의의（P ＝0．018）；식관암환자여비식관암환자hMLH3기인2531위점불동기인형적분포빈솔차이무통계의의（P ＝0．653）；흡연、음주、신랄식물、업훈식물、음수정황、섭입신선소채수과등배경인소균미현시여hM-L H3기인2531위점기인다태성유상관성。결론 hM L H3기인2531위점다태성여신강합살극족식관암가족적취집성상관，미발현hM L H3기인2531위점다태성여신강합살극족식관암적발병급배경인소유관。
Objective To explore the relationship between gene polymorphism of hMLH3 and environmen-tal factors with the esophageal carcinoma in Xinjiang Kazakh esophageal carcinoma family .Methods An on-site survey about the environmental risk factors and a test of hMLH3 gene polymorphism in the periph-eral blood of 86 Xinjiang Kazakh esophageal carcinoma family and 82 comparison family will be adopted . Results The genotype distribution frequency differences of hMLH3 gene 2531 site in Xinjiang Kazakh e-sophageal cancer family and non esophageal cancer family are statistically significant (P = 0 .018);The genotype distribution frequency differences of hMLH3 gene 2531 site in esophageal cancer patients and non-patients are of no statistical significance (P =0 .653);All environmental factors ,such as smoking , drinking ,spicy food ,smoked meat ,drinking water and intake of fresh vegetables and fruit don′t reveal a Objective To explore the relationship between gene polymorphism of hMLH3 and environmen-tal factors with the esophageal carcinoma in Xinjiang Kazakh esophageal carcinoma family .Methods An on-site survey about the environmental risk factors and a test of hMLH3 gene polymorphism in the periph-eral blood of 86 Xinjiang Kazakh esophageal carcinoma family and 82 comparison family will be adopted . Results The genotype distribution frequency differences of hMLH3 gene 2531 site in Xinjiang Kazakh e-sophageal cancer family and non esophageal cancer family are statistically significant (P = 0 .018);The genotype distribution frequency differences of hMLH3 gene 2531 site in esophageal cancer patients and non-patients are of no statistical significance (P =0 .653);All environmental factors ,such as smoking , drinking ,spicy food ,smoked meat ,drinking water and intake of fresh vegetables and fruit don′t reveal a correlation to the gene polymorphism of hMLH3 gene 2531 site .Conclusion The gene polymorphism of hMLH3 gene 2531 site is probably playing some role in the family aggregation of Xinjiang Kazakh esopha-geal cancer ,but neither the correlation between the gene polymorphism of hMLH3 gene 2531 site and the morbidity of Xinjiang Kazakh esophageal cancer was found ,nor the environmental factors .