CAJ | 학술논문

目的探讨新疆地区高血压患者及健康者维生素D、纤维蛋白原（FB ）、白细胞数与高血压的关系及维生素D与FB的相关性。方法对2010年10月-2012年10月在新疆医科大学第一附属医院的326例高血压组患者（病例组）及208例非高血压的健康者（对照组）测定维生素D、FB和白细胞数目，比较两组各指标的差异，并分析病例组中维生素D与FB的相关性。结果病例组与对照组维生素D、FB、白细胞数目、淋巴细胞、中性粒细胞比较差异有统计学意义（ P ＜0．05）。病例组患者维生素D与FB呈负相关（ r ＝-0．652，P ＝0．011），高血压患者维生素D的水平也与病程呈负相关关系（ r ＝-0．742、P ＝0．018）。维生素D、中性粒细胞、纤维蛋白原以及低密度脂蛋白与高血压的发生有关（P ＜0．05）。维生素D为高血压的保护因素（OR ＝0．83，95％ CI 0．795～0．869）。中性粒细胞、纤维蛋白原、低密度脂蛋白为高血压的危险因素（OR值分别为2．141、1．189和2．128，95％ CI分别为1．445～3．173、1．140～1．908和1．840～3．971）。结论高血压患者维生素D水平与FB相关，维生素D为高血压的保护因素，中性粒细胞、纤维蛋白原、低密度脂蛋白为高血压的危险因素。
목적탐토신강지구고혈압환자급건강자유생소D、섬유단백원（FB ）、백세포수여고혈압적관계급유생소D여FB적상관성。방법대2010년10월-2012년10월재신강의과대학제일부속의원적326례고혈압조환자（병례조）급208례비고혈압적건강자（대조조）측정유생소D、FB화백세포수목，비교량조각지표적차이，병분석병례조중유생소D여FB적상관성。결과병례조여대조조유생소D、FB、백세포수목、림파세포、중성립세포비교차이유통계학의의（ P ＜0．05）。병례조환자유생소D여FB정부상관（ r ＝-0．652，P ＝0．011），고혈압환자유생소D적수평야여병정정부상관관계（ r ＝-0．742、P ＝0．018）。유생소D、중성립세포、섬유단백원이급저밀도지단백여고혈압적발생유관（P ＜0．05）。유생소D위고혈압적보호인소（OR ＝0．83，95％ CI 0．795～0．869）。중성립세포、섬유단백원、저밀도지단백위고혈압적위험인소（OR치분별위2．141、1．189화2．128，95％ CI분별위1．445～3．173、1．140～1．908화1．840～3．971）。결론고혈압환자유생소D수평여FB상관，유생소D위고혈압적보호인소，중성립세포、섬유단백원、저밀도지단백위고혈압적위험인소。
Objective To identify relationship between vitamin D ,fibrinogen and high blood pressure . Methods From Oct .2010 to Oct .2012 ,compare to that of 326 cases of patients with hypertension group and 208 healthy group ,determination Fib ,vitamin D and the number of white blood cells by statistics method ,hypertension group and the hypertension group three differences ,to research hypertension group vitamin D and fibrinogen correlation .Results To study healthy group and hypertension group ,vitamin D have statistical significance (P<0 .05) .To compare between ,hypertension group and healthy group about vitamin D ,fibrinogen ,white blood cell number ,lymphocytes ,neutrophils ,blood fat ,exist of exist differ-ence Statistically significant (P < 0 .05) .To analysis the multiple factors regression ,For hypertension , vitamin D is protective factor (B value=0 .186 ,OR value=0 .83 ,95% CI 0 .795 -0 .869) .For hyperten-sion ,Neutrophils ,fibrinogen ,low density lipoprotein are risk factors (B value were 0 .761 ,0 .173 ,0 .987 , OR value were 2 .141 ,1 .189 ,2 .128 ,95% CI 1 .445-3 .1731 ,1 .140-1 .908 ,1 .840-3 .971) .Hyperten-sion group vitamin D and FB have negative correlation (r = 0 .652 , P = 0 .011) .Conclusion Between Objective To identify relationship between vitamin D ,fibrinogen and high blood pressure . Methods From Oct .2010 to Oct .2012 ,compare to that of 326 cases of patients with hypertension group and 208 healthy group ,determination Fib ,vitamin D and the number of white blood cells by statistics method ,hypertension group and the hypertension group three differences ,to research hypertension group vitamin D and fibrinogen correlation .Results To study healthy group and hypertension group ,vitamin D have statistical significance (P<0 .05) .To compare between ,hypertension group and healthy group about vitamin D ,fibrinogen ,white blood cell number ,lymphocytes ,neutrophils ,blood fat ,exist of exist differ-ence Statistically significant (P < 0 .05) .To analysis the multiple factors regression ,For hypertension , vitamin D is protective factor (B value=0 .186 ,OR value=0 .83 ,95% CI 0 .795 -0 .869) .For hyperten-sion ,Neutrophils ,fibrinogen ,low density lipoprotein are risk factors (B value were 0 .761 ,0 .173 ,0 .987 , OR value were 2 .141 ,1 .189 ,2 .128 ,95% CI 1 .445-3 .1731 ,1 .140-1 .908 ,1 .840-3 .971) .Hyperten-sion group vitamin D and FB have negative correlation (r = 0 .652 , P = 0 .011) .Conclusion Between healthy group and hypertension group of vitamin D and fibrinogen is difference .For hypertension vitamin D is protective factor .Neutrophils ,fibrinogen ,low density lipoprotein are risk factors ,find out vitamin D and fibrinogen have negative correlation in the hypertension .