CAJ | 학술논문

目的探讨原发性高血压患者维生素D水平与动脉僵硬程度的相关性。方法选取2010年12月-2012年10月在新疆医科大学第一附属医院高血压科确诊的原发性高血压患者195例为研究对象，根据25（OH）D水平分为维生素D缺乏组（n ＝124）和维生素D非缺乏组（n ＝71），进行临床资料的数据采集，测定踝臂指数（ABI）、踝臂脉搏波传导速度（baPWV）、颈动脉内膜-中层厚度（IMT），分析维生素D与动脉僵硬度的相关性。结果维生素D缺乏组与维生素D非缺乏组25（OH）D水平差异有统计学意义（P＜0．05）。维生素D缺乏组与维生素D非缺乏组ABI、baPWV、IM T比较差异有统计学意义（P＜0．05）。维生素D缺乏组与维生素D非缺乏组立位血管紧张素水平比较差异有统计学意义（P ＜0．05）。维生素D与ABI、颈动脉IMT呈负性相关。多元回归分析显示，ABI与血清25（OH）D独立相关（β＝-0．227，P ＜0．05），颈动脉IMT 与血清25（OH）D独立相关（β＝-0．175，P ＜0．05）。结论原发性高血压伴维生素D缺乏患者动脉僵硬度增加，血清25（OH）D浓度是ABI、颈动脉IM T增加的独立危险因素，维生素D与动脉僵硬度之间可能存在负性相关关系。
목적탐토원발성고혈압환자유생소D수평여동맥강경정도적상관성。방법선취2010년12월-2012년10월재신강의과대학제일부속의원고혈압과학진적원발성고혈압환자195례위연구대상，근거25（OH）D수평분위유생소D결핍조（n ＝124）화유생소D비결핍조（n ＝71），진행림상자료적수거채집，측정과비지수（ABI）、과비맥박파전도속도（baPWV）、경동맥내막-중층후도（IMT），분석유생소D여동맥강경도적상관성。결과유생소D결핍조여유생소D비결핍조25（OH）D수평차이유통계학의의（P＜0．05）。유생소D결핍조여유생소D비결핍조ABI、baPWV、IM T비교차이유통계학의의（P＜0．05）。유생소D결핍조여유생소D비결핍조립위혈관긴장소수평비교차이유통계학의의（P ＜0．05）。유생소D여ABI、경동맥IMT정부성상관。다원회귀분석현시，ABI여혈청25（OH）D독립상관（β＝-0．227，P ＜0．05），경동맥IMT 여혈청25（OH）D독립상관（β＝-0．175，P ＜0．05）。결론원발성고혈압반유생소D결핍환자동맥강경도증가，혈청25（OH）D농도시ABI、경동맥IM T증가적독립위험인소，유생소D여동맥강경도지간가능존재부성상관관계。
Objective To explore the relevance between vitamin D level and arterial stiffness in patients with essential hypertension .Methods 195 cases of patients with essential hypertension selected from hy-pertension patients diagnosed by department of hypertension in First Affiliated Hospital of Xinjiang Medi-cal University from December 2010 to October 2012 as the research object .According to the 25-hydroxyvi-tamin D levels ,we divide the research object into the lack of vitamin D group (n=124) and the no lack of vitamin D group (n =71) ,carry on the clinical data collection ,determination ABI ,baPWV and de carotid artery IM T ,analys the correlation of vitamin D and arterial stiffness .Results Compared the lack of vita-min D group with the no lack of vitamin D group ,25(OH) D levels between the two groups have a signifi-cant statistical difference (P <0 .05) .ABI ,baPWV and carotid artery IM T have statistically significance (P <0 .05) .25(OH)D is negatively correlated with ABI and carotid artery IMT .Vitamin D deficiency is the lack of group and non-group orthostatic angiotensin difference was statistically significant (P<0 .05) . Multiple regression analysis shows that ABI and 25(OH)D associated independently (β= -0 .227 ,P <0 .05) ,carotid artery IMT and 25(OH)D associated independently (β= -0 .175 ,P <0 .05) .Conclusion Vitamin D deficiency in patients with essential hypertension can increase arterial stiffness .Serum 25(OH) D concentration was an independent risk factor of ABI and carotid IM T increased .25-hydroxyvitamin D may have a negative relationship with arterial stiffness .