CAJ | 학술논문

目的：探索普贝生---控释前列腺素E2栓剂用于足月妊娠促宫颈成熟、催产的有效性和安全性。方法：采用随机抽查、对照研究的方法，50例为研究组，予阴道放置普贝生观察；50例对照组，予静脉滴注催产素观察。比较2组孕妇宫颈Bishop评分，分娩情况，对胎儿及新生儿的影响。结果：研究组孕妇用药后2、4、8、12小时宫颈Bishop评分分别为4．0±1．3、4．2±1．2、6．0±1．1和7．6±1．7，明显高于对照组3．7±1．4、3．8±0．8、4．1±1．1和4．6±1．2（P＜0．01）。研究组孕妇临产发动时间、阴道分娩率明显高于对照组（P＜0．01）。产程中研究组胎儿窘迫发生率、出生后1分钟、5分钟Apgan评分与对照组之间无统计学差异（p＞0．&nbsp
목적：탐색보패생---공석전렬선소E2전제용우족월임신촉궁경성숙、최산적유효성화안전성。방법：채용수궤추사、대조연구적방법，50례위연구조，여음도방치보패생관찰；50례대조조，여정맥적주최산소관찰。비교2조잉부궁경Bishop평분，분면정황，대태인급신생인적영향。결과：연구조잉부용약후2、4、8、12소시궁경Bishop평분분별위4．0±1．3、4．2±1．2、6．0±1．1화7．6±1．7，명현고우대조조3．7±1．4、3．8±0．8、4．1±1．1화4．6±1．2（P＜0．01）。연구조잉부임산발동시간、음도분면솔명현고우대조조（P＜0．01）。산정중연구조태인군박발생솔、출생후1분종、5분종Apgan평분여대조조지간무통계학차이（p＞0．&nbsp
Objective:To explore the efficacy and safety of continuously -released dinoprostone suppositories prostaglandin E 2 supposi-tories for cervical ripening in pregnancies .Methods:Using randomized placebo -controlled study ,50 cases as study group ,received a dino-prostone suppositories inserting into vaginal ,while 50 cases as control group received oxytocin through transvenous injecting .The cervical Bishop score ,vaginal delivery rate ,fetal and neonatal condition were compared between the two groups .Results:Cervical score of study group were significantly higher than control group in 2,4,8,12 hours after treatment(p<0.01).The time of labor starting and vaginal delivery rate of study group were significantly higher than control group (p<0.01).The incidence of fetal distress,cervical score of 1 minute and 5minute after birth had not significant difference between the two groups .Over-stimulation of cervix was its main side effects ,but improved immediately after drug removal .Conclusion:Dinoprostone suppositories is effective and safe in producing cervical ripening .