CAJ | 학술논문

目的：探讨舒肝解郁胶囊与帕罗西汀治疗轻中度抑郁症的疗效和不良反应。方法：将60例轻中度抑郁症患者随机分为舒肝解郁组和帕罗西汀组，分别在治疗前、治疗1、2、4、6周使用汉密尔顿抑郁量表（ HAMD）评定疗效，使用副反应量表（TESS）评定不良反应。结果：舒肝解郁胶囊和帕罗西汀对于轻中度抑郁症均有显著疗效，2组疗效无显著差异。但舒肝解郁组的副反应显著低于帕罗西汀组（P≤0．05）。结论：舒肝解郁胶囊治疗轻中度抑郁症疗效明确，较帕罗西汀更为安全。
목적：탐토서간해욱효낭여파라서정치료경중도억욱증적료효화불량반응。방법：장60례경중도억욱증환자수궤분위서간해욱조화파라서정조，분별재치료전、치료1、2、4、6주사용한밀이돈억욱량표（ HAMD）평정료효，사용부반응량표（TESS）평정불량반응。결과：서간해욱효낭화파라서정대우경중도억욱증균유현저료효，2조료효무현저차이。단서간해욱조적부반응현저저우파라서정조（P≤0．05）。결론：서간해욱효낭치료경중도억욱증료효명학，교파라서정경위안전。
Objective:To studying the Shugan Jieyu capsule and paroxetine in the treatment effect of mild to moderate depression and untoward reaction .Methods:60 patients with mild to moderate depression were randomly divided into two groups:before treatment and after treatment (1,2,4,6) weekend,used Hamilton depressive scale (HAMD) to evaluate the effective,used treatment emergent symptom scale (TESS) to evaluate the untoward reaction .Results:Shugan Jieyu capsule and paroxetine both had significant effect in the treatment of mild and moderate depression ,the effective of two groups had no significant differences .But the side effect of Shugan Jieyu capsule was significantly lower than paroxetines′(P≤0.05).Conclusion:Shugan Jieyu capsule might have a clear curative effect in the treatment of mild to moderate depression and it should be safer than paroxetine .