CAJ | 학술논문

目的：比较氨酚羟考酮片及洛芬待因片治疗中、重度急诊创伤疼痛效果及安全性。方法：随机抽取口服氨酚羟考酮片及洛芬待因片治疗中、重度急诊创伤疼痛患者各60例，观察用药第24、48、72小时疼痛缓解程度及其不良反应。结果：2组疼痛强度评估在服药第24、48小时比较均P＞0．05，第72小时比较P＜0．05；服药后24、48、72小时与服药前比较均P＜0．05；治疗重度疼痛，两者第72小时镇痛效果，显效比较P＜0．05，有效比较P＞0．05；治疗中度疼痛，2组第72小时镇痛效果，比较显效、有效均P＞0．05；2组组在服药第24、48、72小时比较不良反应，均P＞0．05。结论：服药72小时疼痛强度（ PI ）评估氨酚羟考酮片优于洛芬待因片，24、48小时比较均无明显差异；服药72小时治疗重度疼痛氨酚羟考酮片组显效优于洛芬待因片组，有效无明显差异，治疗中度疼痛，2组显效、有效均无明显差异。
목적：비교안분간고동편급락분대인편치료중、중도급진창상동통효과급안전성。방법：수궤추취구복안분간고동편급락분대인편치료중、중도급진창상동통환자각60례，관찰용약제24、48、72소시동통완해정도급기불량반응。결과：2조동통강도평고재복약제24、48소시비교균P＞0．05，제72소시비교P＜0．05；복약후24、48、72소시여복약전비교균P＜0．05；치료중도동통，량자제72소시진통효과，현효비교P＜0．05，유효비교P＞0．05；치료중도동통，2조제72소시진통효과，비교현효、유효균P＞0．05；2조조재복약제24、48、72소시비교불량반응，균P＞0．05。결론：복약72소시동통강도（ PI ）평고안분간고동편우우락분대인편，24、48소시비교균무명현차이；복약72소시치료중도동통안분간고동편조현효우우락분대인편조，유효무명현차이，치료중도동통，2조현효、유효균무명현차이。
Objective:To compare the efficacy and safety of acetaminophen and ibuprofen -codeine tablets in patients with trauma pain in emergency room.Methods:Patients were randomly divided into two groups:one -half (n=60) were treated with acetaminophen tablets and another-half (n=60) with ibuprofen-codeine phosphate tablets.The efficacy and side effects were observed 24,48 and 72 h after the treatments.Results:Before treatments,the symptoms were not different in both groups .Both significantly relieved the pain 24, 48 and 72 h after the treatments (P<0.05).There were no significant differences in the two groups at 24 and 48h (P>0.05),but was significant difference (P<0.05) at 72h after the treatments.As compared with both tablets were more effective on serious pain 72h after treatment,but were similarly effective on moderate pain (P>0.05).Side effects were similar in both groups 24,48 and 72h(P>0.05). Conclusion:Acetaminophen tablets were more effective on PI estimation than ibuprofen -codeine tablets 24 and 48h after treatment;how-ever,ibuprofen-codeine tablets are more effective on serious pain than acetaminophen tablets 72 h after treatment .Both tablets were simi-larly effective on moderate pain ,and had similar side effects .