CAJ | 학술논문

目的：探讨CXC族趋化因子受体4(CXCR4)和CC族趋化因子受体7(CCR7)在鼻咽癌(NPC)组织中的表达及其临床意义。方法随机选择2012年1月至2013年10月本院NPC患者60例，取其鼻咽癌组织（病例组），选择同期鼻咽部炎症患者30例，取其鼻咽部组织(对照组)，采用免疫组织化学检测两组患者的CXCR4和CCR7表达情况。结果病例组CCR7和CXCR4的阳性表达分别为32例和27例，均高于对照组的6例和4例，其差异均有统计学意义(P<0.05)，Ⅲ期+Ⅳ期患者的CCR7和CXCR4阳性例数为22例和16例，高于Ⅰ期+Ⅱ期的10例和11例，其差异均具有统计学意义(P<0.05)；M1期CCR7阳性例数为24例，高于M0期的8例，差异也具有统计学意义(P<0.05)；有淋巴结转移的患者CCR7和CXCR4阳性例数分别为23例和24例，未转移者9例和3例，其差异也具有统计学意义(P<0.05)。结论 CCR7和CXCR4在鼻咽癌中的阳性表达率均明显高于非鼻咽癌组织，且与鼻咽癌临床分期和淋巴结转移有关，CXCR4和CCR7在鼻咽癌的发生和发展中具有重要的意义。
목적：탐토CXC족추화인자수체4(CXCR4)화CC족추화인자수체7(CCR7)재비인암(NPC)조직중적표체급기림상의의。방법수궤선택2012년1월지2013년10월본원NPC환자60례，취기비인암조직（병례조），선택동기비인부염증환자30례，취기비인부조직(대조조)，채용면역조직화학검측량조환자적CXCR4화CCR7표체정황。결과병례조CCR7화CXCR4적양성표체분별위32례화27례，균고우대조조적6례화4례，기차이균유통계학의의(P<0.05)，Ⅲ기+Ⅳ기환자적CCR7화CXCR4양성례수위22례화16례，고우Ⅰ기+Ⅱ기적10례화11례，기차이균구유통계학의의(P<0.05)；M1기CCR7양성례수위24례，고우M0기적8례，차이야구유통계학의의(P<0.05)；유림파결전이적환자CCR7화CXCR4양성례수분별위23례화24례，미전이자9례화3례，기차이야구유통계학의의(P<0.05)。결론 CCR7화CXCR4재비인암중적양성표체솔균명현고우비비인암조직，차여비인암림상분기화림파결전이유관，CXCR4화CCR7재비인암적발생화발전중구유중요적의의。
Objective To explore the expression of CXC chemokine receptor-4 (CXCR4) and CC chemo-kine receptor-7 (CCR7) in nasopharyngeal carcinoma (NPC) and its clinical significance. Methods Sixty patients with NPC admitted in our hospital from January 2012 to October 2013 were randomly selected for NPC tissue, which was assigned as the disease group. Another 30 cases with nasopharyngeal inflammation were selected as con-trol group for normal nasopharyngeal tissue. CXCR4 and CCR7 in two groups were detected with expression by im-munohistochemistry. Results The positive expression cases of CCR7 and CXCR4 in the disease group were 32 cases and 27 cases respectively, which were higher than those in the control group with 6 cases and 4 cases, and there were statistically significant different (P<0.05). The positive expression of CCR7 and CXCR4 inⅢstage andⅣstage were 22 cases and 16 cases, which were higher than those inⅠstage andⅡstage with 10 cases and 11 cas-es, and the difference has statistical significance (P<0.05). The positive expression of CCR7 in M1 stage was 24, which was higher than that in M0 stage with 8 cases, and the difference was statistically significant (P<0.05). The positive expression of CCR7 and CXCR4 in patients with lymph node metastasis were 23 cases and 24 cases, which were higher than in patients without metastasis with 9 and 3 cases, and the difference was statistically significant (P<0.05). Conclusion The positive expressions of CCR7 and CXCR4 in patients with NPC were significantly high-er than those in non-carcinoma tissue. It is related with clinical stage and lymph node metastasis. CXCR4 and CCR7 play important roles in the occurrence and development of nasopharyngeal carcinoma.