医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
9期
118-119
,共2页
支气管肺炎%儿童%白细胞介素-8%心肌酶谱
支氣管肺炎%兒童%白細胞介素-8%心肌酶譜
지기관폐염%인동%백세포개소-8%심기매보
Pneumonia%Children%Interleukin-8%Cardiac enzyme
目的探讨白细胞介素-8((interleukin-8, IL-8)及心肌酶谱各指标水平与小儿肺炎的关系。方法随机选取40名重症肺炎、轻型肺炎以及正常对照组儿童作为研究对象，分别在疾病极期和恢复期采用放射免疫法测定血清IL-8水平，日本OlympusAU640全自动生化分析仪检测心肌酶谱，并进行组间比较和相关性分析。结果急性期重症肺炎组和轻型肺炎组患儿IL-8以及心肌酶谱各指标均显著高于正常对照组儿童(P<0.05)；而重症肺炎组患儿上述指标又显著高于轻型肺炎组患儿(P<0.05)。两组患儿恢复期各指标均较急性期明显下降(P<0.05)，而两组患儿恢复期各指标水平与正常对照组比较均无显著差异(P>0.05)。无论重症还是轻型肺炎，急性期IL-8水平与心肌酶谱各指标均呈明显正相关关系(P<0.05)；而恢复期IL-8水平则与心肌酶谱各指标之间并无明显相关关系(P>0.05)。结论：IL-8的变化与心肌酶密切相关，IL-8可做为评估小儿肺炎感染轻重程度及预后判断的监测指标。
目的探討白細胞介素-8((interleukin-8, IL-8)及心肌酶譜各指標水平與小兒肺炎的關繫。方法隨機選取40名重癥肺炎、輕型肺炎以及正常對照組兒童作為研究對象，分彆在疾病極期和恢複期採用放射免疫法測定血清IL-8水平，日本OlympusAU640全自動生化分析儀檢測心肌酶譜，併進行組間比較和相關性分析。結果急性期重癥肺炎組和輕型肺炎組患兒IL-8以及心肌酶譜各指標均顯著高于正常對照組兒童(P<0.05)；而重癥肺炎組患兒上述指標又顯著高于輕型肺炎組患兒(P<0.05)。兩組患兒恢複期各指標均較急性期明顯下降(P<0.05)，而兩組患兒恢複期各指標水平與正常對照組比較均無顯著差異(P>0.05)。無論重癥還是輕型肺炎，急性期IL-8水平與心肌酶譜各指標均呈明顯正相關關繫(P<0.05)；而恢複期IL-8水平則與心肌酶譜各指標之間併無明顯相關關繫(P>0.05)。結論：IL-8的變化與心肌酶密切相關，IL-8可做為評估小兒肺炎感染輕重程度及預後判斷的鑑測指標。
목적탐토백세포개소-8((interleukin-8, IL-8)급심기매보각지표수평여소인폐염적관계。방법수궤선취40명중증폐염、경형폐염이급정상대조조인동작위연구대상，분별재질병겁기화회복기채용방사면역법측정혈청IL-8수평，일본OlympusAU640전자동생화분석의검측심기매보，병진행조간비교화상관성분석。결과급성기중증폐염조화경형폐염조환인IL-8이급심기매보각지표균현저고우정상대조조인동(P<0.05)；이중증폐염조환인상술지표우현저고우경형폐염조환인(P<0.05)。량조환인회복기각지표균교급성기명현하강(P<0.05)，이량조환인회복기각지표수평여정상대조조비교균무현저차이(P>0.05)。무론중증환시경형폐염，급성기IL-8수평여심기매보각지표균정명현정상관관계(P<0.05)；이회복기IL-8수평칙여심기매보각지표지간병무명현상관관계(P>0.05)。결론：IL-8적변화여심기매밀절상관，IL-8가주위평고소인폐염감염경중정도급예후판단적감측지표。
Objective To explore the correlation between interleukin-8 and cardiac enzyme levels in children with bronchopneumonia.Methods About 120 children categorized into severe pneumonia group, mild pneumonia group and control group were recruited into the study. Serum IL-8 (by radioimmunity method) and cardiac enzyme (by Olympus AU640) levels were measured before and after treatment.Results The serum levels of IL-8 and cardiac enzyme in severe and mild pneumonia groups were both higher than those of control group (P<0.05), while those of severe pneumonia group higher than those of mild group (P<0.05). After treatment, all index were significantly decreased compared with basic level (P<0.05). Moreover, statistical correlation was found between serum IL-8 and cardiac enzyme levels before treatment (P<0.05), but not for after treatment. Conclusion IL-8 was closely related with the cardiac enzyme level and IL-8 can be used as a monitoring indicator to assess the severity and prognosis of pneumonia in children.
