医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
9期
100-101
,共2页
支原体肺炎%肺表面活性物质相关蛋白A%基因突变
支原體肺炎%肺錶麵活性物質相關蛋白A%基因突變
지원체폐염%폐표면활성물질상관단백A%기인돌변
Mycoplasma pneumonia%Surfactant protein A%Gene mutations
目的探讨支原体肺炎儿童肺泡表面活性物质蛋白A（SP-A）基因常见突变位点与儿童支原体肺炎发病风险的相关性。方法采用基因测序技术检测支原体肺炎儿童SP-A基因中rs1059054位点、rs1136452位点及rs1136454位点的出现频率。结果对比三个位点的基因频率及等位基因频率发现： rs1136452位点基因频率及等位基因频率在病例组及对照组比较中无统计学差异(P>0.05)；而rs1059054及rs1136454位点基因频率及等位基因频率两组比较均有统计学差异（P<0.05）。结论 rs1059054及rs1136454位点基因多态性可能与儿童支原体肺炎易感性有关。
目的探討支原體肺炎兒童肺泡錶麵活性物質蛋白A（SP-A）基因常見突變位點與兒童支原體肺炎髮病風險的相關性。方法採用基因測序技術檢測支原體肺炎兒童SP-A基因中rs1059054位點、rs1136452位點及rs1136454位點的齣現頻率。結果對比三箇位點的基因頻率及等位基因頻率髮現： rs1136452位點基因頻率及等位基因頻率在病例組及對照組比較中無統計學差異(P>0.05)；而rs1059054及rs1136454位點基因頻率及等位基因頻率兩組比較均有統計學差異（P<0.05）。結論 rs1059054及rs1136454位點基因多態性可能與兒童支原體肺炎易感性有關。
목적탐토지원체폐염인동폐포표면활성물질단백A（SP-A）기인상견돌변위점여인동지원체폐염발병풍험적상관성。방법채용기인측서기술검측지원체폐염인동SP-A기인중rs1059054위점、rs1136452위점급rs1136454위점적출현빈솔。결과대비삼개위점적기인빈솔급등위기인빈솔발현： rs1136452위점기인빈솔급등위기인빈솔재병례조급대조조비교중무통계학차이(P>0.05)；이rs1059054급rs1136454위점기인빈솔급등위기인빈솔량조비교균유통계학차이（P<0.05）。결론 rs1059054급rs1136454위점기인다태성가능여인동지원체폐염역감성유관。
Objective Study of mycoplasma pneumonia in children of pulmonary surfactant protein A (SP-A) gene mutation and common correlation of children mycoplasma pneumonia risk.Methods Using gene sequencing technology detection of mycoplasma pneumonia in children in the SP-A gene rs1059054 site, rs1136452 site and rs1136454 site frequency. Results A comparison of three sites of the gene frequency and al ele frequency was found: rs1136452 gene frequency and al ele frequency showed no significant dif erence in the case group and the control group in (P>0.05); while the rs1059054 and rs1136454 gene frequency and al ele frequency of two compared with significant dif erence (P<0.05).Conclusion Rs1059054 and rs1136454 gene polymorphism may be associated with the susceptibility of mycoplasma pneumonia in children.
