CAJ | 학술논문

目的：分析儿童疑似预防接种异常反应（AEFI）发生情况，以减少AEFI的发生。方法收集2010~2013年儿童疫苗接种及AEFI的登记资料，并进行分析。结果2010~2013年儿童累计预防接种疫苗146348例次，出现AEFI 198例，发生率为135/10万。其中一般反应156例（占78.8%），异常反应26例（占13.1%），偶合症12例（占6.1%），心因性反应4例（占2.0%）。发生率前4位的疫苗是甲型流感疫苗、23价肺炎疫苗、B型流感嗜血杆菌疫苗、百白破疫苗；除1例脊髓灰质炎疫苗相关病例遗留下肢活动障碍外，其余病例均治愈。结论 AEFI多种疫苗均可发生，接种前应注意询问受种者过敏史和近期健康状况，规范接种，做好接种后医学观察，有利于减少AEFI的发生。
목적：분석인동의사예방접충이상반응（AEFI）발생정황，이감소AEFI적발생。방법수집2010~2013년인동역묘접충급AEFI적등기자료，병진행분석。결과2010~2013년인동루계예방접충역묘146348례차，출현AEFI 198례，발생솔위135/10만。기중일반반응156례（점78.8%），이상반응26례（점13.1%），우합증12례（점6.1%），심인성반응4례（점2.0%）。발생솔전4위적역묘시갑형류감역묘、23개폐염역묘、B형류감기혈간균역묘、백백파역묘；제1례척수회질염역묘상관병례유류하지활동장애외，기여병례균치유。결론 AEFI다충역묘균가발생，접충전응주의순문수충자과민사화근기건강상황，규범접충，주호접충후의학관찰，유리우감소AEFI적발생。
Objective To analyze the adverse events following immunization (AEFI) in children, and seek ways to de-crease the incidence rate of AEFI. Methods Collected and analyzed the registation data of immunization and the AEFI in children from 2010 to 2013. Results Vaccinated 146 348 cases from 2010 to 2013,there were 198 cases of AEFI , incidence rate was 135/100 000. Among them 156 cases were non-series events, accounting of 78.8%,paradoxical reaction was 26 cases, accounting of 13.1%,12 cases were coincidence, accounting of 6.1%,the psychogenic reaction was 4 cases, accounting of 2.0%. The top 4 vaccine of incidence rate of AEFI were influenza A vaccine,23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae type B vaccine, DPT vaccine. All the AEFI cases had good prognosis except for polio vaccine assioci-ated paralytic poliomyelitis. Conclusion AEFI occurred in all kinds of vaccines. It is necessary for vaccination providers to conduct health counsel and examination before immunization , standardly inoculate practice and make medicine observation after immunization to ruduce the incidence of AEFI.