CAJ | 학술논문

目的观察双侧颈总动脉永久性结扎后脑缺血致大鼠学习记忆能力的改变。方法将36只大鼠随机分为两组,每组18只。实验组：大鼠用水合氯醛(350mg/kg)腹腔注射麻醉后,双侧颈总动脉永久性结扎。对照组：与实验组做同样手术,但不结扎双侧颈总动脉。造模后第7d、21d后进行Morris水迷宫测试，观察学习记忆能力。结果模型组平均逃避潜伏期(46.58±37.17)s明显延长于对照组(21.21±15.12)s，差异有统计学意义( P<0.05)；模型组 tP/tT 值(0.299±0.079)显著低于对照组(0.458±0.088),差异有统计学意义( P<0.05)。结论海马神经元的损伤与学习记忆关系密切。
목적관찰쌍측경총동맥영구성결찰후뇌결혈치대서학습기억능력적개변。방법장36지대서수궤분위량조,매조18지。실험조：대서용수합록철(350mg/kg)복강주사마취후,쌍측경총동맥영구성결찰。대조조：여실험조주동양수술,단불결찰쌍측경총동맥。조모후제7d、21d후진행Morris수미궁측시，관찰학습기억능력。결과모형조평균도피잠복기(46.58±37.17)s명현연장우대조조(21.21±15.12)s，차이유통계학의의( P<0.05)；모형조 tP/tT 치(0.299±0.079)현저저우대조조(0.458±0.088),차이유통계학의의( P<0.05)。결론해마신경원적손상여학습기억관계밀절。
Objective Cerebral ischemia led to changes of Learning and memory in dementia rat,After permanent bilateral common carotid artery ligated. Methods 36 rats were randomly divided into two groups of 18 rats. Experimental group: After the rats were anesthetized by Abdominal Injection with chloral hydrate (350mg/kg), permanent bilateral common carotid artery ligated. 7、21 days after modeling, Learning and memory of rat in Morris water maze were tested. Results The average escape latency in model group(46.58±37.17)s was significantly longer than in the control group(21.21±15.12)(P<0.05).Platform quadrant(tP)/the total swimming time(tT)in model group(0.299±0.079)was significantly lower than in control group(0.458±0.088)(P<0.05).Conclusion Hippocampal neuronal damage and learning and memory were closely related.