CAJ | 학술논문

目的：探讨神经兴奋性对小鼠学习记忆的影响。方法：每天以2μg/kg ，4μg/kg ，8μg/kg咖啡因和1．25μg/kg ，2．5μg/kg ，5μg/kg氯丙嗪的剂量对小鼠连续腹腔注射3d ，对照组给予生理盐水。采用跳台实验观察大鼠学习记忆能力的改变。结果：每天5μg/kg氯丙嗪组与生理盐水组相比，潜伏期明显延长（ P＜0．05），每天2μg/kg咖啡因组和5μg/kg氯丙嗪组与生理盐水组相比，第二次错误次数（EN2）明显减少（ P＜0．05）。结论：中枢神经系统的兴奋性适度增强和氯丙嗪导致的一过性中枢神经系统多巴胺功能阻断可改善学习记忆。
목적：탐토신경흥강성대소서학습기억적영향。방법：매천이2μg/kg ，4μg/kg ，8μg/kg가배인화1．25μg/kg ，2．5μg/kg ，5μg/kg록병진적제량대소서련속복강주사3d ，대조조급여생리염수。채용도태실험관찰대서학습기억능력적개변。결과：매천5μg/kg록병진조여생리염수조상비，잠복기명현연장（ P＜0．05），매천2μg/kg가배인조화5μg/kg록병진조여생리염수조상비，제이차착오차수（EN2）명현감소（ P＜0．05）。결론：중추신경계통적흥강성괄도증강화록병진도치적일과성중추신경계통다파알공능조단가개선학습기억。
Objective :To explore effects of difference in nerve excitation on mice ability of learning and memory . Methods:Three month old mice were randomly divided into 2 ,4 ,8 μg/kg/d caffeine groups ,1 .25 ,2 . 5 ,5 μg/kg/d chlorpromazine groups and control group .The mice of experimental groups received intraperitoneal in-jection of caffeine or chlorpromazine once daily for 3d .The mice of control group were administered with saline . Platform Experiments were conducted to observe changes in learning and memory abilities .Results :Compared with the saline group ,the incubation period of the 5μg/kg · d chlorpromazine group was significantly longer (P <0 .05) . In addition ,error number 2 (EN2 ) of 2μg/kg · d caffeine group and 5μg/kg · d chlorpromazine group decreased sig-nificantly (P <0 .05) .Conclusion:the moderately enhanced excitability of the central nervous system and a transi-ent block of the dopamine function caused by chlorpromazine can improve learning and memory ability of mice .