CAJ | 학술논문

目的对CYP2C 19的基因多态性与风险评分对冠状动脉介入术(PCI)预后的关系进行分析探讨.方法从2012年3月至2012年7月接收的行PCI患者中随机抽选40例,入院之前统一抽血检查CYP2C19基因,将患者按CYP2C19基因型分为三组:慢代谢型患者,中代谢型患者,和快代谢型患者.结果经过检测,PRI VASP≥50％的患者为6例,PRI VASP＜50％的患者为34例,两组间PRI VASP比为(55.97±2.98)比(44.01±4.16),两组比较差异有统计学意义(P＜0.05).通过多元回归分析对导致PCI术后不良终点事件的因素进行分析得出:老龄、CYP2C19慢性代谢、2型糖尿病、左室射血分值、肾功能不全等5项因素为高危险因素.结论对于慢代谢者可以通过增加氯吡格雷药物剂量,并联合给服阿司匹林以预防心血管事件发作.
목적 대CYP2C 19적기인다태성여풍험평분대관상동맥개입술(PCI)예후적관계진행분석탐토.방법 종2012년3월지2012년7월접수적행PCI환자중수궤추선40례,입원지전통일추혈검사CYP2C19기인,장환자안CYP2C19기인형분위삼조:만대사형환자,중대사형환자,화쾌대사형환자.결과 경과검측,PRI VASP≥50％적환자위6례,PRI VASP＜50％적환자위34례,량조간PRI VASP비위(55.97±2.98)비(44.01±4.16),량조비교차이유통계학의의(P＜0.05).통과다원회귀분석대도치PCI술후불량종점사건적인소진행분석득출:노령、CYP2C19만성대사、2형당뇨병、좌실사혈분치、신공능불전등5항인소위고위험인소.결론 대우만대사자가이통과증가록필격뢰약물제량,병연합급복아사필림이예방심혈관사건발작.
Objective To investigate the relation between CYP2C19 polymorphisms and risk score and prognosis after percutaneous coronary intervention (PCI).Methods From March in 2012 to July in 2012 we randomly selected 40 patients who received PCI treatment and took their blood for the test of CYP2C 19 before admission.The CYP2C 19 genotypes were divided into three groups:extensive metabolisms,medium metabolisms and poor metabolisms.Results The PRI VASP ≥ 50％ of the patients in 6 cases,the PRI VASP ＜ 50％ of the patients in 34 cases,between the two groups of PRI VASP ratio of (55.97 ± 2.98) than (44.01-± 4.16),the difference had statistical significance (P ＜ 0.05).Through multiple regression analysis,this paper analyzes the factors which lead to the PCI postoperative adverse end point events concluded:aging,CYP2C19 poor metabolism,T2DM,LVEF,Renal insufficiency,the five factors for the high risk factors.Conclusion For patients with poor metabolism we can increase the dose of clopidogrel and combining Aspirin to prevent heart attacks.