CAJ | 학술논문

目的对艾滋病合并马尔尼菲青霉病的临床特点、诊断及治疗进行分析。方法回顾性分析我院2008年4月～2012年12月收治的215例艾滋病合并马尔尼菲青霉病病例资料，将使用两性霉素B后口服3个月伊曲康唑分为A组，使用两性霉素B后口服半年伊曲康唑为B组，比较两组疗效。结果A组治愈率为87.50%，复发率为0.89%；B组分别为74.76%、2.91%；两组疗效均显著，复发率低，两组治愈率比较差异无统计学意义（P＞0.05）。结论南方地区艾滋病患者容易合并马尔尼菲青霉菌感染，皮疹和发热是早期临床的表现血培阳性是诊断的金标准之一，同时结合临床表现、皮肤溃疡活检或多部位取材培养是提高确诊的方法，早期诊断及时给予两性霉素B+伊曲康唑治疗可提高疗效，降低复发。
목적대애자병합병마이니비청매병적림상특점、진단급치료진행분석。방법회고성분석아원2008년4월～2012년12월수치적215례애자병합병마이니비청매병병례자료，장사용량성매소B후구복3개월이곡강서분위A조，사용량성매소B후구복반년이곡강서위B조，비교량조료효。결과A조치유솔위87.50%，복발솔위0.89%；B조분별위74.76%、2.91%；량조료효균현저，복발솔저，량조치유솔비교차이무통계학의의（P＞0.05）。결론남방지구애자병환자용역합병마이니비청매균감염，피진화발열시조기림상적표현혈배양성시진단적금표준지일，동시결합림상표현、피부궤양활검혹다부위취재배양시제고학진적방법，조기진단급시급여량성매소B+이곡강서치료가제고료효，강저복발。
Objective To analyze the clinical features, diagnosis and treatment of AIDS complicated with penicilliosis marneffei. Methods 215 cases of clinical data of AIDS complicated with penicilliosis marneffei in our hospital from April 2008 to December 2012 were retrospectively analyzed. The cases administrated orally with itraconazole for 3 months after the oral administration of amphotericin B were divided into group A, and the cases administrated orally with itraconazole for 6 months after the administration of amphotericin B were divided into group B. Results The cure rate of group A was 87.50%and the recurrence rate was 0.89%;and they were 74.76%and 2.91%respectively in group B; the curative effects of the two groups were significant and the recurrence rates were low. There was no statistical significance of cure rate between the two groups (P>0.05). Conclusion AIDS patients in southern region are easy to be infected with penicilliosis marneffei. Skin rashes and fever are early clinical signs, and positive blood culture is one of the gold standards for diagnosis, which are the methods to improve the diagnosis combining with clinical manifestations, biopsy of skin ulcer and sampling in different regions for culture. Early diagnosis and administration of amphotericin B+itraconazole in time can improve the curative effect to reduce the recurrence.