CAJ | 학술논문

目的观察氟康唑在治疗老年口腔念珠菌的临床效果。方法选取我院2011年10月～2012年4月老年口腔白念珠菌患者80例，按照患者本人的用药情况将其分为观察组和对照组各40例。观察组给予氟康唑治疗，对照组给予制霉菌素治疗，比较两组患者的临床疗效。结果观察组的总有效率95.0%明显高于对照组87.5%，但差异无统计学意义（P＞0.05）；停药6个月进行复查，观察组复发率（27.5%）明显低于对照组（47.5%），差异有统计学意义（P＜0.05）。结论氟康唑和制霉菌素单纯使用在治疗老年口腔念珠菌病上均有疗效，但氟康唑是长期疗效的首选药物。
목적관찰불강서재치료노년구강념주균적림상효과。방법선취아원2011년10월～2012년4월노년구강백념주균환자80례，안조환자본인적용약정황장기분위관찰조화대조조각40례。관찰조급여불강서치료，대조조급여제매균소치료，비교량조환자적림상료효。결과관찰조적총유효솔95.0%명현고우대조조87.5%，단차이무통계학의의（P＞0.05）；정약6개월진행복사，관찰조복발솔（27.5%）명현저우대조조（47.5%），차이유통계학의의（P＜0.05）。결론불강서화제매균소단순사용재치료노년구강념주균병상균유료효，단불강서시장기료효적수선약물。
Objective To explore the the clinical effect of Fluconazole in treatment of elderly oral candidiasis. Methods Selected 80 elderly patients with oral candidiasis from Oct. 2011 to Apr.2012 in our hospital were divided into observation group and control group (each 40 cases ) according to patients` determination. The observation group was given Fluconazole,and the control group was given Nystatin, the clinical effect of both groups were observed and compared. Results The total effect rate in observation group(95.0%) was higher than that in control group(87.5%),with non-significant difference(P>0.05);The total patients were reexamined 6 months after discontinuation when the skin lesions and other symptoms disappeared, The recurrence rate in observation group (27.5%)was obviously lower than that in control group (47.5%),with significant difference(P <0.05). Conclusion Fluconazole and Nystatin both can treat elderly oral candidiasis, but Fluconazole is the preferred drug for long-term effect in elderly patients.