CAJ | 학술논문

目的考察载阿霉素金磁复合微粒在外磁场的协同作用下，对小鼠肝细胞癌的靶向治疗效果。方法建立小鼠肝细胞癌动物模型，随机分为5组，每组10只，各组经尾缘静脉分别注射生理盐水、单纯磁微粒溶液、及含有同等剂量阿霉素的磁微粒溶液和单纯阿霉素溶液，同时，在注射磁阿霉素溶液的一组中，加外磁场固定2h。上述各组给药治疗每3天进行1次，分别于第6天和第9天测算各组肿瘤抑制率，评价其抗肿瘤效果。结果磁阿霉素加磁场组较其他各组均有明显的抑瘤效果（P=0.000），并在持续给药的情况下，对肿瘤的抑制效果不断增强，而在无外磁场的环境下，单纯阿霉素组和单纯磁阿霉素组虽有抑瘤作用，但两者抑瘤效果无差异（P＞0.05），单纯磁微粒组无抑瘤作用。结论通过磁导靶向给药，载阿霉素金磁复合微粒对小鼠肝细胞癌具有明显的抑制作用，有望成为临床靶向治疗恶性肿瘤的一种新途径。
목적고찰재아매소금자복합미립재외자장적협동작용하，대소서간세포암적파향치료효과。방법건립소서간세포암동물모형，수궤분위5조，매조10지，각조경미연정맥분별주사생리염수、단순자미립용액、급함유동등제량아매소적자미립용액화단순아매소용액，동시，재주사자아매소용액적일조중，가외자장고정2h。상술각조급약치료매3천진행1차，분별우제6천화제9천측산각조종류억제솔，평개기항종류효과。결과자아매소가자장조교기타각조균유명현적억류효과（P=0.000），병재지속급약적정황하，대종류적억제효과불단증강，이재무외자장적배경하，단순아매소조화단순자아매소조수유억류작용，단량자억류효과무차이（P＞0.05），단순자미립조무억류작용。결론통과자도파향급약，재아매소금자복합미립대소서간세포암구유명현적억제작용，유망성위림상파향치료악성종류적일충신도경。
Objective To explore the targeting therapeutic effect of doxorubicin-loaded gold magnetic composite particles combined with an external magnetic field on mice with hepatocellular carcinoma. Methods A total of 50 mice were randomLy divided into 5 groups, and given saline,doxorubicin,magnetic composite particles,doxorubicin-loaded magnetic composite particles,respectively;and the fifth group was given doxorubicin-loaded magnetic composite particles with an external magnetic field. The targeting treatment was conducted every three days. On Day 6 and Day 9,tumor inhibition ratio of each group was measured,and anti-tumor effect was evaluated. Results The group given doxorubicin-loaded magnetic composite particle with an external magnetic field had statistically different anti-tumor effect compared with other treatment group(P=0.000),which strengthened with continuous drug delivery.The tumor inhibition was no statistically significant difference between the pure magnetic particle group and the pure doxorubicin group (P>0.05). The pure magnetic particles had no inhibition effect on tumor. Conclusion Doxorubicin-loaded magnetic composite particle combined with an external magnetic field had good tumor inhibition effect,and could be a new treatment for tumor.