CAJ | 학술논문

目的了解新生儿重症监护病房（NICU）内呼吸机相关性肺炎（VAP）的发病率，有针对性地采取防控措施。方法采用目标性监测，对本院2010年1月～2012年12月NICU患者VAP的发病情况进行监测，并提出具体的防控措施。结果监测期间共发生VAP 28例次，呼吸机使用天数689 d，VAP发病率20.14%，日感染率40.64‰。2010、2011和2012年日感染率比较，差异有统计学意义（x2=6.67，P＜0.05）。不同胎龄、出生体重、机械通气时间、插管次数，患者VAP感染率比较，差异均有统计学意义（P＜0.05）。28例VAP患者呼吸道分泌物中共培养出病原菌30株，其中耐药菌13株。结论开展目标性监测可有效降低VAP感染的发生，同时为VAP的经验性治疗提供依据。
목적료해신생인중증감호병방（NICU）내호흡궤상관성폐염（VAP）적발병솔，유침대성지채취방공조시。방법채용목표성감측，대본원2010년1월～2012년12월NICU환자VAP적발병정황진행감측，병제출구체적방공조시。결과감측기간공발생VAP 28례차，호흡궤사용천수689 d，VAP발병솔20.14%，일감염솔40.64‰。2010、2011화2012년일감염솔비교，차이유통계학의의（x2=6.67，P＜0.05）。불동태령、출생체중、궤계통기시간、삽관차수，환자VAP감염솔비교，차이균유통계학의의（P＜0.05）。28례VAP환자호흡도분비물중공배양출병원균30주，기중내약균13주。결론개전목표성감측가유효강저VAP감염적발생，동시위VAP적경험성치료제공의거。
Objective To investigate the incidence of ventilator-associated pneumonia(VAP)in neonatal intensive care unit(NICU),and to propose targeted prevention and control measures. Methods Taret monitoring was applied to investigate the incidence of VAP in NICU from January 2010 to December 2012,for proposing specific prevention and control measures. Results 28 cases of VAP were noted during the monitor period.Total number of ventilation days were 689 d.The incidence of VAP was 20.14%.Daily VAP infection rate was 40.64‰,with statistical differences among the years of 2010,2011 and 2012(x2=6.67,P < 0.05).VAP incidence rates among infants with different gestation,born weight,ventilation time,and intubation frequency were significantly different(P < 0.05).A total of 30 strains of pathogenic bacteria were isolated from respiratory secretions of the 28 cases,and 13 strains were resistant to antibiotics. Conclusion Targeted monitoring can reduce the infection rate of VAP effectively,and provide the basis for empiric therapy.