CAJ | 학술논문

目的探讨长托宁与阿托品治疗急性有机磷农药中毒的临床疗效比较。方法将84例患者根据治疗方法的不同分为观察组和对照组各42例，观察组在常规治疗的基础上给予长托宁治疗，对照组在常规治疗的基础上给予阿托品治疗。结果观察组在治愈率、病死率、症状消失时间、用药次数、用药总量、胆碱酯酶恢复时间、住院时间及不良反应方面均优于对照组，两组比较差异均有统计学意义（P＜0.05）。结论长托宁治疗急性有机磷农药中毒疗效显著，能够有效缩短症状消失时间和住院时间，提高治愈率和降低病死率，具有用药少、起效快、作用时间长及不良反应少、安全性高、高选择性等优点，值得临床推广应用。
목적탐토장탁저여아탁품치료급성유궤린농약중독적림상료효비교。방법장84례환자근거치료방법적불동분위관찰조화대조조각42례，관찰조재상규치료적기출상급여장탁저치료，대조조재상규치료적기출상급여아탁품치료。결과관찰조재치유솔、병사솔、증상소실시간、용약차수、용약총량、담감지매회복시간、주원시간급불량반응방면균우우대조조，량조비교차이균유통계학의의（P＜0.05）。결론장탁저치료급성유궤린농약중독료효현저，능구유효축단증상소실시간화주원시간，제고치유솔화강저병사솔，구유용약소、기효쾌、작용시간장급불량반응소、안전성고、고선택성등우점，치득림상추엄응용。
Objective To explore and compare the clinical curative effects of penehyclidine and atropine on patients with acute organophosphorus pesticide poisoning. Methods 84 patients according to the different treatments divided into observation group and control group (42 cases in each group).The observation group was additionally treated with penehyclidine on the basis of conventional treatment,while the control group was additionally treated with atropine. Results The cure rate,case fatality rate,disappear time of symptoms,medication frequency,total amount of medication,recovery time of cholinesterase, hospitalization time and adverse reactions of the observation group were better than these of the control group with significant differences (P<0.05). Conclusion The clinical curative effect of penehyclidine on patients with acute organophosphorus pesticide poisoning is significant,which can effectively reduce the disappeared time of symptoms and hospitalization time,improve the cure rate and reduce the case fatality rate.It has the advantages of less medication, fast onset of action,long acting time, less adverse reactions,high safety,and high selectivity,which is worthy of clinical popularization and application.