CAJ | 학술논문

目的探讨阿奇霉素与氯霉素治疗恙虫病的临床疗效。方法根据治疗方法的不同将54例患儿分为观察组和对照组各27例，观察组给予阿奇霉素治疗，对照组给予氯霉素治疗。结果两组患儿均痊愈出院，痊愈率均为100%，差异无统计学意义（P＞0.05）；两组患儿在体温恢复正常时间、焦痂脱落时间及住院时间比较差异均无统计学意义（P＞0.05）；但观察组不良反应发生率为11.1%，明显低于对照组的25.9%，两组比较差异具有统计学意义（P＜0.05）。结论应用阿奇霉素和氯霉素治疗恙虫病均能够取得较好疗效，但阿奇霉素具有较低不良反应发生率，不会对儿童的生长发育产生影响。
목적탐토아기매소여록매소치료양충병적림상료효。방법근거치료방법적불동장54례환인분위관찰조화대조조각27례，관찰조급여아기매소치료，대조조급여록매소치료。결과량조환인균전유출원，전유솔균위100%，차이무통계학의의（P＞0.05）；량조환인재체온회복정상시간、초가탈락시간급주원시간비교차이균무통계학의의（P＞0.05）；단관찰조불량반응발생솔위11.1%，명현저우대조조적25.9%，량조비교차이구유통계학의의（P＜0.05）。결론응용아기매소화록매소치료양충병균능구취득교호료효，단아기매소구유교저불량반응발생솔，불회대인동적생장발육산생영향。
Objective To investigate and compare the clinical effects of azithromycin and chloromycetin on tsutsugamushi disease. Methods 54 sick children were divided into observation group and control group,depending on the treatment.Each group had 27 cases.Azithromycin was administrated to sick children of observation group,and chloromycetin was administrated to sick children of control group. Results Sick children of two groups were completely cured and left hospital,with the cure rate of 100%(P > 0.05);there were no significant differences in the recovery time of body temperature,eschar-off time and hospital stays between two groups(P > 0.05);but the incidence of adverse effect of observation group was 11.1%,which was lower than 25.9%of control group obviously,and the difference between two groups was statistically difference(P < 0.05). Conclusion Both of azithromycin and chloromycet have effects on tsutsugamushi disease.However,azithromycin has no impact on the growth of children due to its lower incidence of adverse effect.